FGF/FGFR signaling pathway involved resistance in various cancer types

Resistance becomes major clinical issue in cancer treatment, which strongly limits patients to benefit from oncotherapy. Growing evidences have been indicative of the critical role of fibroblast growth factor (FGF)/receptor (FGFR) signaling played in resistance to oncotherapy. In this review we disc...

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Detalles Bibliográficos
Autores principales: Zhou, Yangyang, Wu, Chengyu, Lu, Guangrong, Hu, Zijing, Chen, Qiuxiang, Du, Xiaojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052940/
https://www.ncbi.nlm.nih.gov/pubmed/32127928
http://dx.doi.org/10.7150/jca.40531
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author Zhou, Yangyang
Wu, Chengyu
Lu, Guangrong
Hu, Zijing
Chen, Qiuxiang
Du, Xiaojing
author_facet Zhou, Yangyang
Wu, Chengyu
Lu, Guangrong
Hu, Zijing
Chen, Qiuxiang
Du, Xiaojing
author_sort Zhou, Yangyang
collection PubMed
description Resistance becomes major clinical issue in cancer treatment, which strongly limits patients to benefit from oncotherapy. Growing evidences have been indicative of the critical role of fibroblast growth factor (FGF)/receptor (FGFR) signaling played in resistance to oncotherapy. In this review we discussed the underlying mechanisms of FGF/FGFR signaling mediated resistance to chemotherapy, radiotherapy and target therapy in various cancers. Meanwhile, we summarized the reported mechanism of FGF/FGFR inhibitors resistance in cancers.
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spelling pubmed-70529402020-03-03 FGF/FGFR signaling pathway involved resistance in various cancer types Zhou, Yangyang Wu, Chengyu Lu, Guangrong Hu, Zijing Chen, Qiuxiang Du, Xiaojing J Cancer Review Resistance becomes major clinical issue in cancer treatment, which strongly limits patients to benefit from oncotherapy. Growing evidences have been indicative of the critical role of fibroblast growth factor (FGF)/receptor (FGFR) signaling played in resistance to oncotherapy. In this review we discussed the underlying mechanisms of FGF/FGFR signaling mediated resistance to chemotherapy, radiotherapy and target therapy in various cancers. Meanwhile, we summarized the reported mechanism of FGF/FGFR inhibitors resistance in cancers. Ivyspring International Publisher 2020-02-03 /pmc/articles/PMC7052940/ /pubmed/32127928 http://dx.doi.org/10.7150/jca.40531 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Zhou, Yangyang
Wu, Chengyu
Lu, Guangrong
Hu, Zijing
Chen, Qiuxiang
Du, Xiaojing
FGF/FGFR signaling pathway involved resistance in various cancer types
title FGF/FGFR signaling pathway involved resistance in various cancer types
title_full FGF/FGFR signaling pathway involved resistance in various cancer types
title_fullStr FGF/FGFR signaling pathway involved resistance in various cancer types
title_full_unstemmed FGF/FGFR signaling pathway involved resistance in various cancer types
title_short FGF/FGFR signaling pathway involved resistance in various cancer types
title_sort fgf/fgfr signaling pathway involved resistance in various cancer types
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052940/
https://www.ncbi.nlm.nih.gov/pubmed/32127928
http://dx.doi.org/10.7150/jca.40531
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