An engineering probiotic producing defensin-5 ameliorating dextran sodium sulfate-induced mice colitis via Inhibiting NF-kB pathway

BACKGROUND: Human defensin-5 (HD-5) is a key antimicrobial peptide which plays an important role in host immune defense, while the short half-life greatly limits its clinical application. The purpose of this study was to investigate the effects of an engineering probiotic producing HD-5 on intestina...

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Detalles Bibliográficos
Autores principales: Zeng, Lishan, Tan, Jiasheng, Xue, Meng, Liu, Le, Wang, Mingming, Liang, Liping, Deng, Jun, Chen, Wei, Chen, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053090/
https://www.ncbi.nlm.nih.gov/pubmed/32122364
http://dx.doi.org/10.1186/s12967-020-02272-5

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