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Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects

This review aims to present completed clinical trial data surrounding the medicinal benefits and potential side effects of the increasingly popular cannabidiol (CBD)-based drug products, specifically Epidiolex. The article is divided into two sections based on if the ailment being treated by this ca...

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Autores principales: Pauli, Christopher S., Conroy, Matthieu, Vanden Heuvel, Brian D., Park, Sang-Hyuck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053164/
https://www.ncbi.nlm.nih.gov/pubmed/32161538
http://dx.doi.org/10.3389/fphar.2020.00063
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author Pauli, Christopher S.
Conroy, Matthieu
Vanden Heuvel, Brian D.
Park, Sang-Hyuck
author_facet Pauli, Christopher S.
Conroy, Matthieu
Vanden Heuvel, Brian D.
Park, Sang-Hyuck
author_sort Pauli, Christopher S.
collection PubMed
description This review aims to present completed clinical trial data surrounding the medicinal benefits and potential side effects of the increasingly popular cannabidiol (CBD)-based drug products, specifically Epidiolex. The article is divided into two sections based on if the ailment being treated by this cannabinoid is classified as either physiological or neurological conditions. In addition to describing the current status, we also examined the different primary and secondary outcomes recorded for each study, which varies greatly depending on the funding source of the clinical trial. With the recent FDA-approval of Epidiolex, this review mainly focused on trials involving this specific formulation since it is the only CBD-based drug currently available to clinicians, although all other clinically trialed CBD(A) drugs were also examined. We hope this review will help guide future research and clinical trials by providing the various outcomes measured in a single review.
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spelling pubmed-70531642020-03-11 Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects Pauli, Christopher S. Conroy, Matthieu Vanden Heuvel, Brian D. Park, Sang-Hyuck Front Pharmacol Pharmacology This review aims to present completed clinical trial data surrounding the medicinal benefits and potential side effects of the increasingly popular cannabidiol (CBD)-based drug products, specifically Epidiolex. The article is divided into two sections based on if the ailment being treated by this cannabinoid is classified as either physiological or neurological conditions. In addition to describing the current status, we also examined the different primary and secondary outcomes recorded for each study, which varies greatly depending on the funding source of the clinical trial. With the recent FDA-approval of Epidiolex, this review mainly focused on trials involving this specific formulation since it is the only CBD-based drug currently available to clinicians, although all other clinically trialed CBD(A) drugs were also examined. We hope this review will help guide future research and clinical trials by providing the various outcomes measured in a single review. Frontiers Media S.A. 2020-02-25 /pmc/articles/PMC7053164/ /pubmed/32161538 http://dx.doi.org/10.3389/fphar.2020.00063 Text en Copyright © 2020 Pauli, Conroy, Vanden Heuvel and Park http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Pauli, Christopher S.
Conroy, Matthieu
Vanden Heuvel, Brian D.
Park, Sang-Hyuck
Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects
title Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects
title_full Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects
title_fullStr Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects
title_full_unstemmed Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects
title_short Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects
title_sort cannabidiol drugs clinical trial outcomes and adverse effects
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053164/
https://www.ncbi.nlm.nih.gov/pubmed/32161538
http://dx.doi.org/10.3389/fphar.2020.00063
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