Risk factors of the efficacy of hepatitis B vaccine in health-care workers

BACKGROUND: Conventional hepatitis B virus vaccination fails to achieve efficient protection in about 5%–10% of the world population. Different factors influence the immunogenicity of hepatitis B vaccine. This study aimed to evaluate these factors in health-care workers. MATERIALS AND METHODS: This...

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Detalles Bibliográficos
Autores principales: Salehi, Hassan, Salehi, Marzieh, Kalbasi, Nader, Salehi, Maryam, Sharifian, Jalil, Salehi, Mohammad Mahdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053165/
https://www.ncbi.nlm.nih.gov/pubmed/32174987
http://dx.doi.org/10.4103/jrms.JRMS_1054_18
Descripción
Sumario:BACKGROUND: Conventional hepatitis B virus vaccination fails to achieve efficient protection in about 5%–10% of the world population. Different factors influence the immunogenicity of hepatitis B vaccine. This study aimed to evaluate these factors in health-care workers. MATERIALS AND METHODS: This was a descriptive study which was implemented among 140 of medical and dental staff working as health-care workers who were low responder after vaccination entered the study. RESULTS: Age (>40 years), weight (body mass index >25), immunodeficiency diseases, (primary immune deficiency and immunosuppressant drugs), diabetes mellitus, and smoking were the important factors. CONCLUSION: In the high-risk group of hepatitis B disease, the risk factors of immunogenicity must be evaluated at vaccination and check titers of antibody after vaccination.

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