Immunization with the Gly(1127)-Cys(1140) amino acid sequence of the LRP1 receptor reduces atherosclerosis in rabbits. Molecular, immunohistochemical and nuclear imaging studies

Background: The LRP1 (CR9) domain and, in particular, the sequence Gly(1127)-Cys(1140) (P3) plays a critical role in the binding and internalization of aggregated LDL (agLDL). We aimed to evaluate whether immunization with P3 reduces high-fat diet (HFD)-induced atherosclerosis. Methods: Female New Z...

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Detalles Bibliográficos
Autores principales: Bornachea, Olga, Benitez-Amaro, Aleyda, Vea, Angela, Nasarre, Laura, de Gonzalo-Calvo, David, Escola-Gil, Juan Carlos, Cedo, Lidia, Iborra, Antoni, Martínez-Martínez, Laura, Juarez, Candido, Camara, Juan Antonio, Espinet, Carina, Borrell-Pages, Maria, Badimon, Lina, Castell, Joan, Llorente-Cortés, Vicenta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053206/
https://www.ncbi.nlm.nih.gov/pubmed/32194867
http://dx.doi.org/10.7150/thno.37305

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