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An evolving paradigm of cancer stem cell hierarchies: therapeutic implications
Over a decade of research has confirmed the critical role of cancer stem-like cells (CSCs) in tumor initiation, chemoresistance, and metastasis. Increasingly, CSC hierarchies have begun to be defined with some recurring themes. This includes evidence that these hierarchies are 'flexible,'...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053211/ https://www.ncbi.nlm.nih.gov/pubmed/32194856 http://dx.doi.org/10.7150/thno.41647 |
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author | Cole, Alexander J Fayomi, Adetunji P Anyaeche, Vivian I Bai, Shoumei Buckanovich, Ronald J |
author_facet | Cole, Alexander J Fayomi, Adetunji P Anyaeche, Vivian I Bai, Shoumei Buckanovich, Ronald J |
author_sort | Cole, Alexander J |
collection | PubMed |
description | Over a decade of research has confirmed the critical role of cancer stem-like cells (CSCs) in tumor initiation, chemoresistance, and metastasis. Increasingly, CSC hierarchies have begun to be defined with some recurring themes. This includes evidence that these hierarchies are 'flexible,' with both cell state transitions and dedifferentiation events possible. These findings pose therapeutic hurdles and opportunities. Here, we review cancer stem cell hierarchies and their interactions with the tumor microenvironment. We also discuss the current therapeutic approaches designed to target CSC hierarchies and initial clinical trial results for CSC targeting agents. While cancer stem cell targeted therapies are still in their infancy, we are beginning to see encouraging results that suggest a positive outlook for CSC-targeting approaches. |
format | Online Article Text |
id | pubmed-7053211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-70532112020-03-19 An evolving paradigm of cancer stem cell hierarchies: therapeutic implications Cole, Alexander J Fayomi, Adetunji P Anyaeche, Vivian I Bai, Shoumei Buckanovich, Ronald J Theranostics Review Over a decade of research has confirmed the critical role of cancer stem-like cells (CSCs) in tumor initiation, chemoresistance, and metastasis. Increasingly, CSC hierarchies have begun to be defined with some recurring themes. This includes evidence that these hierarchies are 'flexible,' with both cell state transitions and dedifferentiation events possible. These findings pose therapeutic hurdles and opportunities. Here, we review cancer stem cell hierarchies and their interactions with the tumor microenvironment. We also discuss the current therapeutic approaches designed to target CSC hierarchies and initial clinical trial results for CSC targeting agents. While cancer stem cell targeted therapies are still in their infancy, we are beginning to see encouraging results that suggest a positive outlook for CSC-targeting approaches. Ivyspring International Publisher 2020-02-10 /pmc/articles/PMC7053211/ /pubmed/32194856 http://dx.doi.org/10.7150/thno.41647 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Cole, Alexander J Fayomi, Adetunji P Anyaeche, Vivian I Bai, Shoumei Buckanovich, Ronald J An evolving paradigm of cancer stem cell hierarchies: therapeutic implications |
title | An evolving paradigm of cancer stem cell hierarchies: therapeutic implications |
title_full | An evolving paradigm of cancer stem cell hierarchies: therapeutic implications |
title_fullStr | An evolving paradigm of cancer stem cell hierarchies: therapeutic implications |
title_full_unstemmed | An evolving paradigm of cancer stem cell hierarchies: therapeutic implications |
title_short | An evolving paradigm of cancer stem cell hierarchies: therapeutic implications |
title_sort | evolving paradigm of cancer stem cell hierarchies: therapeutic implications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053211/ https://www.ncbi.nlm.nih.gov/pubmed/32194856 http://dx.doi.org/10.7150/thno.41647 |
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