Cargando…

Role of the NLRP3 Inflammasome in Preeclampsia

Reproduction involves tightly regulated series of events and the immune system is involved in an array of reproductive processes. Disruption of well-controlled immune functions leads to infertility, placental inflammation, and numerous pregnancy complications, including preeclampsia (PE). Inflammaso...

Descripción completa

Detalles Bibliográficos
Autores principales: Shirasuna, Koumei, Karasawa, Tadayoshi, Takahashi, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053284/
https://www.ncbi.nlm.nih.gov/pubmed/32161574
http://dx.doi.org/10.3389/fendo.2020.00080
_version_ 1783503010469511168
author Shirasuna, Koumei
Karasawa, Tadayoshi
Takahashi, Masafumi
author_facet Shirasuna, Koumei
Karasawa, Tadayoshi
Takahashi, Masafumi
author_sort Shirasuna, Koumei
collection PubMed
description Reproduction involves tightly regulated series of events and the immune system is involved in an array of reproductive processes. Disruption of well-controlled immune functions leads to infertility, placental inflammation, and numerous pregnancy complications, including preeclampsia (PE). Inflammasomes are involved in the process of pathogen clearance and sterile inflammation. They are large multi-protein complexes that are located in the cytosol and play key roles in the production of the pivotal inflammatory cytokines, interleukin (IL)-1β and IL-18, and pyroptosis. The nucleotide-binding oligomerization domain, leucine-rich repeat-, and pyrin domain-containing 3 (NLRP3) inflammasome is a key mediator of sterile inflammation induced by various types of damage-associated molecular patterns (DAMPs). Recent evidence indicates that the NLRP3 inflammasome is involved in pregnancy dysfunction, including PE. Many DAMPs (uric acid, palmitic acid, high-mobility group box 1, advanced glycation end products, extracellular vesicles, cell-free DNA, and free fatty acids) are increased and associated with pregnancy complications, especially PE. This review focuses on the role of the NLRP3 inflammasome in the pathophysiology of PE.
format Online
Article
Text
id pubmed-7053284
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-70532842020-03-11 Role of the NLRP3 Inflammasome in Preeclampsia Shirasuna, Koumei Karasawa, Tadayoshi Takahashi, Masafumi Front Endocrinol (Lausanne) Endocrinology Reproduction involves tightly regulated series of events and the immune system is involved in an array of reproductive processes. Disruption of well-controlled immune functions leads to infertility, placental inflammation, and numerous pregnancy complications, including preeclampsia (PE). Inflammasomes are involved in the process of pathogen clearance and sterile inflammation. They are large multi-protein complexes that are located in the cytosol and play key roles in the production of the pivotal inflammatory cytokines, interleukin (IL)-1β and IL-18, and pyroptosis. The nucleotide-binding oligomerization domain, leucine-rich repeat-, and pyrin domain-containing 3 (NLRP3) inflammasome is a key mediator of sterile inflammation induced by various types of damage-associated molecular patterns (DAMPs). Recent evidence indicates that the NLRP3 inflammasome is involved in pregnancy dysfunction, including PE. Many DAMPs (uric acid, palmitic acid, high-mobility group box 1, advanced glycation end products, extracellular vesicles, cell-free DNA, and free fatty acids) are increased and associated with pregnancy complications, especially PE. This review focuses on the role of the NLRP3 inflammasome in the pathophysiology of PE. Frontiers Media S.A. 2020-02-25 /pmc/articles/PMC7053284/ /pubmed/32161574 http://dx.doi.org/10.3389/fendo.2020.00080 Text en Copyright © 2020 Shirasuna, Karasawa and Takahashi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Shirasuna, Koumei
Karasawa, Tadayoshi
Takahashi, Masafumi
Role of the NLRP3 Inflammasome in Preeclampsia
title Role of the NLRP3 Inflammasome in Preeclampsia
title_full Role of the NLRP3 Inflammasome in Preeclampsia
title_fullStr Role of the NLRP3 Inflammasome in Preeclampsia
title_full_unstemmed Role of the NLRP3 Inflammasome in Preeclampsia
title_short Role of the NLRP3 Inflammasome in Preeclampsia
title_sort role of the nlrp3 inflammasome in preeclampsia
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053284/
https://www.ncbi.nlm.nih.gov/pubmed/32161574
http://dx.doi.org/10.3389/fendo.2020.00080
work_keys_str_mv AT shirasunakoumei roleofthenlrp3inflammasomeinpreeclampsia
AT karasawatadayoshi roleofthenlrp3inflammasomeinpreeclampsia
AT takahashimasafumi roleofthenlrp3inflammasomeinpreeclampsia