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Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy
Pregnancy constitutes a major challenge to the maternal immune system, which must tolerate fetal alloantigen encoded by paternal genes. In addition to their role in inducing maternal-fetal immune tolerance, accumulating evidence indicates that decidual immune cells are involved in several processes...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053337/ https://www.ncbi.nlm.nih.gov/pubmed/32140065 http://dx.doi.org/10.7150/ijbs.38264 |
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author | Chang, Rui-Qi Zhou, Wen-Jie Li, Da-Jin Li, Ming-Qing |
author_facet | Chang, Rui-Qi Zhou, Wen-Jie Li, Da-Jin Li, Ming-Qing |
author_sort | Chang, Rui-Qi |
collection | PubMed |
description | Pregnancy constitutes a major challenge to the maternal immune system, which must tolerate fetal alloantigen encoded by paternal genes. In addition to their role in inducing maternal-fetal immune tolerance, accumulating evidence indicates that decidual immune cells are involved in several processes required for a successful pregnancy, including trophoblast invasion as well as tissue and spiral artery remodeling. Innate lymphoid cells (ILCs), an important branch of the innate immune system, which has expanded rapidly in recent years, are strong actors in mucosal immunity, tissue homeostasis and metabolism regulation. With the recent identification of ILCs in the human decidua, the role of ILCs at the maternal-fetal interface raises concern. Herein, we review the presence and characterization of ILCs in the human decidua, as well as their function in normal pregnancy and pathological pregnancy, including reproductive failure, preeclampsia and others. |
format | Online Article Text |
id | pubmed-7053337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-70533372020-03-05 Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy Chang, Rui-Qi Zhou, Wen-Jie Li, Da-Jin Li, Ming-Qing Int J Biol Sci Review Pregnancy constitutes a major challenge to the maternal immune system, which must tolerate fetal alloantigen encoded by paternal genes. In addition to their role in inducing maternal-fetal immune tolerance, accumulating evidence indicates that decidual immune cells are involved in several processes required for a successful pregnancy, including trophoblast invasion as well as tissue and spiral artery remodeling. Innate lymphoid cells (ILCs), an important branch of the innate immune system, which has expanded rapidly in recent years, are strong actors in mucosal immunity, tissue homeostasis and metabolism regulation. With the recent identification of ILCs in the human decidua, the role of ILCs at the maternal-fetal interface raises concern. Herein, we review the presence and characterization of ILCs in the human decidua, as well as their function in normal pregnancy and pathological pregnancy, including reproductive failure, preeclampsia and others. Ivyspring International Publisher 2020-01-30 /pmc/articles/PMC7053337/ /pubmed/32140065 http://dx.doi.org/10.7150/ijbs.38264 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Chang, Rui-Qi Zhou, Wen-Jie Li, Da-Jin Li, Ming-Qing Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy |
title | Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy |
title_full | Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy |
title_fullStr | Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy |
title_full_unstemmed | Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy |
title_short | Innate Lymphoid Cells at the Maternal-Fetal Interface in Human Pregnancy |
title_sort | innate lymphoid cells at the maternal-fetal interface in human pregnancy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053337/ https://www.ncbi.nlm.nih.gov/pubmed/32140065 http://dx.doi.org/10.7150/ijbs.38264 |
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