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Acute Synovitis after Trauma Precedes and is Associated with Osteoarthritis Onset and Progression

Osteoarthritis (OA) is a whole-joint disease characterized by cartilage destruction, subchondral bone sclerosis, osteophyte formation, and synovitis. However, it remains unclear which part of the joint undergoes initial pathological changes that drives OA onset and progression. In the present study,...

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Autores principales: Liao, Lifan, Zhang, Shanxing, Zhao, Lan, Chang, Xiaofeng, Han, Lin, Huang, Jian, Chen, Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053339/
https://www.ncbi.nlm.nih.gov/pubmed/32140066
http://dx.doi.org/10.7150/ijbs.39015
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author Liao, Lifan
Zhang, Shanxing
Zhao, Lan
Chang, Xiaofeng
Han, Lin
Huang, Jian
Chen, Di
author_facet Liao, Lifan
Zhang, Shanxing
Zhao, Lan
Chang, Xiaofeng
Han, Lin
Huang, Jian
Chen, Di
author_sort Liao, Lifan
collection PubMed
description Osteoarthritis (OA) is a whole-joint disease characterized by cartilage destruction, subchondral bone sclerosis, osteophyte formation, and synovitis. However, it remains unclear which part of the joint undergoes initial pathological changes that drives OA onset and progression. In the present study, we investigated the longitudinal alterations of the entire knee joint using a surgically-induced OA mouse model. Histology analysis showed that synovitis occurred as early as 1 week after destabilization of the medial meniscus (DMM), which preceded the events of cartilage degradation, subchondral sclerosis and osteophyte formation. Importantly, key pro-inflammatory cytokines such as IL-1β, IL-6, TNFα, and Ccl2, major matrix degrading enzymes including Adamts4, Mmp3 and Mmp13, as well as nerve growth factor (NGF), all increased significantly in both synovium and articular cartilage. It is notable that the inductions of these factors in synovium are far more extensive than those in articular cartilage. Results from behavioral tests demonstrated that sensitization of knee joint pain developed after 8 weeks, later than histological and molecular changes. In addition, the nanoindentation modulus of the medial tibiae decreased 4 weeks after DMM surgery, simultaneous with histological OA signs, which is also later than appearance of synovitis. Collectively, our data suggested that synovitis precedes and is associated with OA, and thus synovium may be an important target to intervene in OA treatment.
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spelling pubmed-70533392020-03-05 Acute Synovitis after Trauma Precedes and is Associated with Osteoarthritis Onset and Progression Liao, Lifan Zhang, Shanxing Zhao, Lan Chang, Xiaofeng Han, Lin Huang, Jian Chen, Di Int J Biol Sci Research Paper Osteoarthritis (OA) is a whole-joint disease characterized by cartilage destruction, subchondral bone sclerosis, osteophyte formation, and synovitis. However, it remains unclear which part of the joint undergoes initial pathological changes that drives OA onset and progression. In the present study, we investigated the longitudinal alterations of the entire knee joint using a surgically-induced OA mouse model. Histology analysis showed that synovitis occurred as early as 1 week after destabilization of the medial meniscus (DMM), which preceded the events of cartilage degradation, subchondral sclerosis and osteophyte formation. Importantly, key pro-inflammatory cytokines such as IL-1β, IL-6, TNFα, and Ccl2, major matrix degrading enzymes including Adamts4, Mmp3 and Mmp13, as well as nerve growth factor (NGF), all increased significantly in both synovium and articular cartilage. It is notable that the inductions of these factors in synovium are far more extensive than those in articular cartilage. Results from behavioral tests demonstrated that sensitization of knee joint pain developed after 8 weeks, later than histological and molecular changes. In addition, the nanoindentation modulus of the medial tibiae decreased 4 weeks after DMM surgery, simultaneous with histological OA signs, which is also later than appearance of synovitis. Collectively, our data suggested that synovitis precedes and is associated with OA, and thus synovium may be an important target to intervene in OA treatment. Ivyspring International Publisher 2020-01-30 /pmc/articles/PMC7053339/ /pubmed/32140066 http://dx.doi.org/10.7150/ijbs.39015 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Liao, Lifan
Zhang, Shanxing
Zhao, Lan
Chang, Xiaofeng
Han, Lin
Huang, Jian
Chen, Di
Acute Synovitis after Trauma Precedes and is Associated with Osteoarthritis Onset and Progression
title Acute Synovitis after Trauma Precedes and is Associated with Osteoarthritis Onset and Progression
title_full Acute Synovitis after Trauma Precedes and is Associated with Osteoarthritis Onset and Progression
title_fullStr Acute Synovitis after Trauma Precedes and is Associated with Osteoarthritis Onset and Progression
title_full_unstemmed Acute Synovitis after Trauma Precedes and is Associated with Osteoarthritis Onset and Progression
title_short Acute Synovitis after Trauma Precedes and is Associated with Osteoarthritis Onset and Progression
title_sort acute synovitis after trauma precedes and is associated with osteoarthritis onset and progression
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053339/
https://www.ncbi.nlm.nih.gov/pubmed/32140066
http://dx.doi.org/10.7150/ijbs.39015
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