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Small molecule NSC1892 targets the CUL4A/4B-DDB1 interactions and causes impairment of CRL4(DCAF4) E3 ligases to inhibit colorectal cancer cell growth

Cullin 4A and 4B (CUL4A and 4B) function as oncogenes in colorectal cancer (CRC) cells. Both of them conservatively associate with DNA damage-binding protein 1 (DDB1) and DDB1-CUL4-associated factor 4 (DCAF4) to form Cullin-RING E3 ligases known as CRL4(DCAF4), which specifically ubiquitinate and de...

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Detalles Bibliográficos
Autores principales: Yang, Chunmei, Wu, Jing, He, Hongbo, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053343/
https://www.ncbi.nlm.nih.gov/pubmed/32140073
http://dx.doi.org/10.7150/ijbs.40235