Dietary Depletion of Milk Exosomes and Their MicroRNA Cargos Elicits a Depletion of miR-200a-3p and Elevated Intestinal Inflammation and Chemokine (C-X-C Motif) Ligand 9 Expression in Mdr1a(−/−) Mice

BACKGROUND: Exosomes transfer regulatory microRNAs (miRs) from donor cells to recipient cells. Exosomes and miRs originate from both endogenous synthesis and dietary sources such as milk. miR-200a-3p is a negative regulator of the proinflammatory chemokine (C-X-C motif) ligand 9 (CXCL9). Male Mdr1a(...

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Detalles Bibliográficos
Autores principales: Wu, Di, Kittana, Hatem, Shu, Jiang, Kachman, Stephen D, Cui, Juan, Ramer-Tait, Amanda E, Zempleni, Janos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053579/
https://www.ncbi.nlm.nih.gov/pubmed/32154493
http://dx.doi.org/10.1093/cdn/nzz122

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