Cargando…
The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation
IL-33 is an important member of the IL-1 family which has pleiotropic activities in innate and adaptive immune responses. Recently, some researchers have focused on the function of cellular immunity in the development of tumor. The biological role of IL-33 in glioma is poorly understood. In this stu...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053587/ https://www.ncbi.nlm.nih.gov/pubmed/32003751 http://dx.doi.org/10.18632/aging.102707 |
_version_ | 1783503064558206976 |
---|---|
author | Lin, Lin Li, Yang Liu, Mingli Li, Qingbin Liu, Quan Li, Ruiyan |
author_facet | Lin, Lin Li, Yang Liu, Mingli Li, Qingbin Liu, Quan Li, Ruiyan |
author_sort | Lin, Lin |
collection | PubMed |
description | IL-33 is an important member of the IL-1 family which has pleiotropic activities in innate and adaptive immune responses. Recently, some researchers have focused on the function of cellular immunity in the development of tumor. The biological role of IL-33 in glioma is poorly understood. In this study, we showed that glioma cells and tissues expressed higher levels of IL-33 and its receptor ST2 compared to normal brain. Clinically, IL-33 expression was associated with poor survival in patients with glioma. Administration of human IL-33 enhanced cell migration, invasion, epithelial to mesenchymal transition and stemness. Anti-ST2 blocked these effects of IL-33 on tumor. Mechanistically, IL-33 activated JNK signaling pathway via ST2 and increased the expression of key transcription factors that controlled the process of EMT and stemness. Moreover, IL-33 prevented temozolomide induced tumor apoptosis. Anti-ST2 or knockdown IL-33 increased the sensitivity of tumor to temozolomide. Thus, targeting the IL-33/ST2 axis may offer an opportunity to the treatment of glioma patients. |
format | Online Article Text |
id | pubmed-7053587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-70535872020-03-12 The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation Lin, Lin Li, Yang Liu, Mingli Li, Qingbin Liu, Quan Li, Ruiyan Aging (Albany NY) Research Paper IL-33 is an important member of the IL-1 family which has pleiotropic activities in innate and adaptive immune responses. Recently, some researchers have focused on the function of cellular immunity in the development of tumor. The biological role of IL-33 in glioma is poorly understood. In this study, we showed that glioma cells and tissues expressed higher levels of IL-33 and its receptor ST2 compared to normal brain. Clinically, IL-33 expression was associated with poor survival in patients with glioma. Administration of human IL-33 enhanced cell migration, invasion, epithelial to mesenchymal transition and stemness. Anti-ST2 blocked these effects of IL-33 on tumor. Mechanistically, IL-33 activated JNK signaling pathway via ST2 and increased the expression of key transcription factors that controlled the process of EMT and stemness. Moreover, IL-33 prevented temozolomide induced tumor apoptosis. Anti-ST2 or knockdown IL-33 increased the sensitivity of tumor to temozolomide. Thus, targeting the IL-33/ST2 axis may offer an opportunity to the treatment of glioma patients. Impact Journals 2020-01-29 /pmc/articles/PMC7053587/ /pubmed/32003751 http://dx.doi.org/10.18632/aging.102707 Text en Copyright © 2020 Lin et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Lin, Lin Li, Yang Liu, Mingli Li, Qingbin Liu, Quan Li, Ruiyan The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation |
title | The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation |
title_full | The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation |
title_fullStr | The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation |
title_full_unstemmed | The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation |
title_short | The Interleukin-33/ST2 axis promotes glioma mesenchymal transition, stemness and TMZ resistance via JNK activation |
title_sort | interleukin-33/st2 axis promotes glioma mesenchymal transition, stemness and tmz resistance via jnk activation |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053587/ https://www.ncbi.nlm.nih.gov/pubmed/32003751 http://dx.doi.org/10.18632/aging.102707 |
work_keys_str_mv | AT linlin theinterleukin33st2axispromotesgliomamesenchymaltransitionstemnessandtmzresistanceviajnkactivation AT liyang theinterleukin33st2axispromotesgliomamesenchymaltransitionstemnessandtmzresistanceviajnkactivation AT liumingli theinterleukin33st2axispromotesgliomamesenchymaltransitionstemnessandtmzresistanceviajnkactivation AT liqingbin theinterleukin33st2axispromotesgliomamesenchymaltransitionstemnessandtmzresistanceviajnkactivation AT liuquan theinterleukin33st2axispromotesgliomamesenchymaltransitionstemnessandtmzresistanceviajnkactivation AT liruiyan theinterleukin33st2axispromotesgliomamesenchymaltransitionstemnessandtmzresistanceviajnkactivation AT linlin interleukin33st2axispromotesgliomamesenchymaltransitionstemnessandtmzresistanceviajnkactivation AT liyang interleukin33st2axispromotesgliomamesenchymaltransitionstemnessandtmzresistanceviajnkactivation AT liumingli interleukin33st2axispromotesgliomamesenchymaltransitionstemnessandtmzresistanceviajnkactivation AT liqingbin interleukin33st2axispromotesgliomamesenchymaltransitionstemnessandtmzresistanceviajnkactivation AT liuquan interleukin33st2axispromotesgliomamesenchymaltransitionstemnessandtmzresistanceviajnkactivation AT liruiyan interleukin33st2axispromotesgliomamesenchymaltransitionstemnessandtmzresistanceviajnkactivation |