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Association of cardiovascular structure and function with cerebrovascular changes and cognitive function in older patients with end-stage renal disease

The Dutch prospective multicenter cohort study COPE (Cognitive decline in Older Patients with End stage renal disease) aimed to investigate the association of cardiovascular structure and function with cerebrovascular changes and cognitive function in 85 older patients with chronic kidney disease st...

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Autores principales: Zijlstra, Laurien E., Trompet, Stella, Jukema, J. Wouter, Kroft, Lucia J. M., de Bresser, Jeroen, van Osch, Matthias J. P., Hammer, Sebastiaan, Witjes, Marie-Noëlle, van Buren, Marjolijn, Mooijaart, Simon P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053617/
https://www.ncbi.nlm.nih.gov/pubmed/31907337
http://dx.doi.org/10.18632/aging.102696
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author Zijlstra, Laurien E.
Trompet, Stella
Jukema, J. Wouter
Kroft, Lucia J. M.
de Bresser, Jeroen
van Osch, Matthias J. P.
Hammer, Sebastiaan
Witjes, Marie-Noëlle
van Buren, Marjolijn
Mooijaart, Simon P.
author_facet Zijlstra, Laurien E.
Trompet, Stella
Jukema, J. Wouter
Kroft, Lucia J. M.
de Bresser, Jeroen
van Osch, Matthias J. P.
Hammer, Sebastiaan
Witjes, Marie-Noëlle
van Buren, Marjolijn
Mooijaart, Simon P.
author_sort Zijlstra, Laurien E.
collection PubMed
description The Dutch prospective multicenter cohort study COPE (Cognitive decline in Older Patients with End stage renal disease) aimed to investigate the association of cardiovascular structure and function with cerebrovascular changes and cognitive function in 85 older patients with chronic kidney disease stage 4 and 5, awaiting either dialysis or conservative care. MRI was performed measuring aortic stiffness (pulse wave velocity [PWV]) and cardiac systolic function (ejection fraction and cardiac index). Outcomes were MRI-derived cerebrovascular changes (microbleeds, lacunes and white matter hyperintensities) and cognitive function (memory, executive function and psychomotor speed). Mean age was 76 years and 66% were male. No statistically significant associations were observed between cardiovascular parameters and cerebrovascular changes. Cognitive function was worse in patients with high compared to low PWV in all three cognitive domains. Although there were clinically relevant associations of high PWV with poor cognition in all domains, after adjustment for age, sex and education only the Trail Making Test A remained statistically significant (p=0.030). In conclusion, this study suggests that a higher PWV might be associated with lower cognitive function, suggesting that arterial stiffness may be an underlying mechanism of development of cognitive impairment in older patients with ESRD. Larger studies should replicate and extend these findings.
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spelling pubmed-70536172020-03-12 Association of cardiovascular structure and function with cerebrovascular changes and cognitive function in older patients with end-stage renal disease Zijlstra, Laurien E. Trompet, Stella Jukema, J. Wouter Kroft, Lucia J. M. de Bresser, Jeroen van Osch, Matthias J. P. Hammer, Sebastiaan Witjes, Marie-Noëlle van Buren, Marjolijn Mooijaart, Simon P. Aging (Albany NY) Research Paper The Dutch prospective multicenter cohort study COPE (Cognitive decline in Older Patients with End stage renal disease) aimed to investigate the association of cardiovascular structure and function with cerebrovascular changes and cognitive function in 85 older patients with chronic kidney disease stage 4 and 5, awaiting either dialysis or conservative care. MRI was performed measuring aortic stiffness (pulse wave velocity [PWV]) and cardiac systolic function (ejection fraction and cardiac index). Outcomes were MRI-derived cerebrovascular changes (microbleeds, lacunes and white matter hyperintensities) and cognitive function (memory, executive function and psychomotor speed). Mean age was 76 years and 66% were male. No statistically significant associations were observed between cardiovascular parameters and cerebrovascular changes. Cognitive function was worse in patients with high compared to low PWV in all three cognitive domains. Although there were clinically relevant associations of high PWV with poor cognition in all domains, after adjustment for age, sex and education only the Trail Making Test A remained statistically significant (p=0.030). In conclusion, this study suggests that a higher PWV might be associated with lower cognitive function, suggesting that arterial stiffness may be an underlying mechanism of development of cognitive impairment in older patients with ESRD. Larger studies should replicate and extend these findings. Impact Journals 2020-01-07 /pmc/articles/PMC7053617/ /pubmed/31907337 http://dx.doi.org/10.18632/aging.102696 Text en Copyright © 2020 Zijlstra et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zijlstra, Laurien E.
Trompet, Stella
Jukema, J. Wouter
Kroft, Lucia J. M.
de Bresser, Jeroen
van Osch, Matthias J. P.
Hammer, Sebastiaan
Witjes, Marie-Noëlle
van Buren, Marjolijn
Mooijaart, Simon P.
Association of cardiovascular structure and function with cerebrovascular changes and cognitive function in older patients with end-stage renal disease
title Association of cardiovascular structure and function with cerebrovascular changes and cognitive function in older patients with end-stage renal disease
title_full Association of cardiovascular structure and function with cerebrovascular changes and cognitive function in older patients with end-stage renal disease
title_fullStr Association of cardiovascular structure and function with cerebrovascular changes and cognitive function in older patients with end-stage renal disease
title_full_unstemmed Association of cardiovascular structure and function with cerebrovascular changes and cognitive function in older patients with end-stage renal disease
title_short Association of cardiovascular structure and function with cerebrovascular changes and cognitive function in older patients with end-stage renal disease
title_sort association of cardiovascular structure and function with cerebrovascular changes and cognitive function in older patients with end-stage renal disease
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053617/
https://www.ncbi.nlm.nih.gov/pubmed/31907337
http://dx.doi.org/10.18632/aging.102696
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