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Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis

Several studies have indicated that the use of antihypertensive medications may influence the incidence of bladder/kidney cancer, with some scholars refuting any such association. Hence, a systematic review is needed to verify this linkage. we comprehensively searched PubMed, Embase, Web of Science,...

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Autores principales: Xie, Yuxiu, Xu, Peng, Wang, Meng, Zheng, Yi, Tian, Tian, Yang, Si, Deng, Yujiao, Wu, Ying, Zhai, Zhen, Hao, Qian, Song, Dingli, Zhang, Dai, Dai, Zhijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053620/
https://www.ncbi.nlm.nih.gov/pubmed/31968309
http://dx.doi.org/10.18632/aging.102699
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author Xie, Yuxiu
Xu, Peng
Wang, Meng
Zheng, Yi
Tian, Tian
Yang, Si
Deng, Yujiao
Wu, Ying
Zhai, Zhen
Hao, Qian
Song, Dingli
Zhang, Dai
Dai, Zhijun
author_facet Xie, Yuxiu
Xu, Peng
Wang, Meng
Zheng, Yi
Tian, Tian
Yang, Si
Deng, Yujiao
Wu, Ying
Zhai, Zhen
Hao, Qian
Song, Dingli
Zhang, Dai
Dai, Zhijun
author_sort Xie, Yuxiu
collection PubMed
description Several studies have indicated that the use of antihypertensive medications may influence the incidence of bladder/kidney cancer, with some scholars refuting any such association. Hence, a systematic review is needed to verify this linkage. we comprehensively searched PubMed, Embase, Web of Science, and the Cochrane Library for original studies reporting a relationship between antihypertensive medications and risk of bladder/kidney cancer. We included 31 articles comprising 3,352,264 participants. We found a significant association between the risk of kidney cancer and any antihypertensive medications use (relative risk (RR) = 1.45, 95% CI 1.20-1.75), as well as angiotensin-converting enzyme inhibitors (RR = 1.24, 95% CI 1.04-1.48), angiotensin II receptor blockers (ARB) (RR = 1.29, 95% CI:1.22-1.37), beta-blockers (RR = 1.36, 95% CI 1.11-1.66), calcium-channel blockers (RR = 1.65, 95% CI 1.54-1.78) and diuretics (RR = 1.34, 95% CI 1.19-1.51). In case of bladder cancer, a statistical significance was observed with the use of ARB (RR = 1.07, 95% CI 1.03-1.11) but not with the other antihypertensive medications. There was a linear association between the duration of antihypertensive medications and the risk of kidney cancer (P = 0.061 for a non-linear trend) and the pooled RR for the per year increase in antihypertensive medications duration of use was 1.02 (95% CI: 1.01-1.02). Our results indicate that there is a significant association between each class of antihypertensive medications and the risk of kidney cancer, and this trend presented as a positive linear association. Furthermore, the use of ARB has been linked to the risk of bladder cancer.
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spelling pubmed-70536202020-03-12 Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis Xie, Yuxiu Xu, Peng Wang, Meng Zheng, Yi Tian, Tian Yang, Si Deng, Yujiao Wu, Ying Zhai, Zhen Hao, Qian Song, Dingli Zhang, Dai Dai, Zhijun Aging (Albany NY) Research Paper Several studies have indicated that the use of antihypertensive medications may influence the incidence of bladder/kidney cancer, with some scholars refuting any such association. Hence, a systematic review is needed to verify this linkage. we comprehensively searched PubMed, Embase, Web of Science, and the Cochrane Library for original studies reporting a relationship between antihypertensive medications and risk of bladder/kidney cancer. We included 31 articles comprising 3,352,264 participants. We found a significant association between the risk of kidney cancer and any antihypertensive medications use (relative risk (RR) = 1.45, 95% CI 1.20-1.75), as well as angiotensin-converting enzyme inhibitors (RR = 1.24, 95% CI 1.04-1.48), angiotensin II receptor blockers (ARB) (RR = 1.29, 95% CI:1.22-1.37), beta-blockers (RR = 1.36, 95% CI 1.11-1.66), calcium-channel blockers (RR = 1.65, 95% CI 1.54-1.78) and diuretics (RR = 1.34, 95% CI 1.19-1.51). In case of bladder cancer, a statistical significance was observed with the use of ARB (RR = 1.07, 95% CI 1.03-1.11) but not with the other antihypertensive medications. There was a linear association between the duration of antihypertensive medications and the risk of kidney cancer (P = 0.061 for a non-linear trend) and the pooled RR for the per year increase in antihypertensive medications duration of use was 1.02 (95% CI: 1.01-1.02). Our results indicate that there is a significant association between each class of antihypertensive medications and the risk of kidney cancer, and this trend presented as a positive linear association. Furthermore, the use of ARB has been linked to the risk of bladder cancer. Impact Journals 2020-01-22 /pmc/articles/PMC7053620/ /pubmed/31968309 http://dx.doi.org/10.18632/aging.102699 Text en Copyright © 2020 Xie et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Xie, Yuxiu
Xu, Peng
Wang, Meng
Zheng, Yi
Tian, Tian
Yang, Si
Deng, Yujiao
Wu, Ying
Zhai, Zhen
Hao, Qian
Song, Dingli
Zhang, Dai
Dai, Zhijun
Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis
title Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis
title_full Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis
title_fullStr Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis
title_full_unstemmed Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis
title_short Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis
title_sort antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053620/
https://www.ncbi.nlm.nih.gov/pubmed/31968309
http://dx.doi.org/10.18632/aging.102699
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