Cargando…
Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis
Several studies have indicated that the use of antihypertensive medications may influence the incidence of bladder/kidney cancer, with some scholars refuting any such association. Hence, a systematic review is needed to verify this linkage. we comprehensively searched PubMed, Embase, Web of Science,...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053620/ https://www.ncbi.nlm.nih.gov/pubmed/31968309 http://dx.doi.org/10.18632/aging.102699 |
_version_ | 1783503072445595648 |
---|---|
author | Xie, Yuxiu Xu, Peng Wang, Meng Zheng, Yi Tian, Tian Yang, Si Deng, Yujiao Wu, Ying Zhai, Zhen Hao, Qian Song, Dingli Zhang, Dai Dai, Zhijun |
author_facet | Xie, Yuxiu Xu, Peng Wang, Meng Zheng, Yi Tian, Tian Yang, Si Deng, Yujiao Wu, Ying Zhai, Zhen Hao, Qian Song, Dingli Zhang, Dai Dai, Zhijun |
author_sort | Xie, Yuxiu |
collection | PubMed |
description | Several studies have indicated that the use of antihypertensive medications may influence the incidence of bladder/kidney cancer, with some scholars refuting any such association. Hence, a systematic review is needed to verify this linkage. we comprehensively searched PubMed, Embase, Web of Science, and the Cochrane Library for original studies reporting a relationship between antihypertensive medications and risk of bladder/kidney cancer. We included 31 articles comprising 3,352,264 participants. We found a significant association between the risk of kidney cancer and any antihypertensive medications use (relative risk (RR) = 1.45, 95% CI 1.20-1.75), as well as angiotensin-converting enzyme inhibitors (RR = 1.24, 95% CI 1.04-1.48), angiotensin II receptor blockers (ARB) (RR = 1.29, 95% CI:1.22-1.37), beta-blockers (RR = 1.36, 95% CI 1.11-1.66), calcium-channel blockers (RR = 1.65, 95% CI 1.54-1.78) and diuretics (RR = 1.34, 95% CI 1.19-1.51). In case of bladder cancer, a statistical significance was observed with the use of ARB (RR = 1.07, 95% CI 1.03-1.11) but not with the other antihypertensive medications. There was a linear association between the duration of antihypertensive medications and the risk of kidney cancer (P = 0.061 for a non-linear trend) and the pooled RR for the per year increase in antihypertensive medications duration of use was 1.02 (95% CI: 1.01-1.02). Our results indicate that there is a significant association between each class of antihypertensive medications and the risk of kidney cancer, and this trend presented as a positive linear association. Furthermore, the use of ARB has been linked to the risk of bladder cancer. |
format | Online Article Text |
id | pubmed-7053620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-70536202020-03-12 Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis Xie, Yuxiu Xu, Peng Wang, Meng Zheng, Yi Tian, Tian Yang, Si Deng, Yujiao Wu, Ying Zhai, Zhen Hao, Qian Song, Dingli Zhang, Dai Dai, Zhijun Aging (Albany NY) Research Paper Several studies have indicated that the use of antihypertensive medications may influence the incidence of bladder/kidney cancer, with some scholars refuting any such association. Hence, a systematic review is needed to verify this linkage. we comprehensively searched PubMed, Embase, Web of Science, and the Cochrane Library for original studies reporting a relationship between antihypertensive medications and risk of bladder/kidney cancer. We included 31 articles comprising 3,352,264 participants. We found a significant association between the risk of kidney cancer and any antihypertensive medications use (relative risk (RR) = 1.45, 95% CI 1.20-1.75), as well as angiotensin-converting enzyme inhibitors (RR = 1.24, 95% CI 1.04-1.48), angiotensin II receptor blockers (ARB) (RR = 1.29, 95% CI:1.22-1.37), beta-blockers (RR = 1.36, 95% CI 1.11-1.66), calcium-channel blockers (RR = 1.65, 95% CI 1.54-1.78) and diuretics (RR = 1.34, 95% CI 1.19-1.51). In case of bladder cancer, a statistical significance was observed with the use of ARB (RR = 1.07, 95% CI 1.03-1.11) but not with the other antihypertensive medications. There was a linear association between the duration of antihypertensive medications and the risk of kidney cancer (P = 0.061 for a non-linear trend) and the pooled RR for the per year increase in antihypertensive medications duration of use was 1.02 (95% CI: 1.01-1.02). Our results indicate that there is a significant association between each class of antihypertensive medications and the risk of kidney cancer, and this trend presented as a positive linear association. Furthermore, the use of ARB has been linked to the risk of bladder cancer. Impact Journals 2020-01-22 /pmc/articles/PMC7053620/ /pubmed/31968309 http://dx.doi.org/10.18632/aging.102699 Text en Copyright © 2020 Xie et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Xie, Yuxiu Xu, Peng Wang, Meng Zheng, Yi Tian, Tian Yang, Si Deng, Yujiao Wu, Ying Zhai, Zhen Hao, Qian Song, Dingli Zhang, Dai Dai, Zhijun Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis |
title | Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis |
title_full | Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis |
title_fullStr | Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis |
title_full_unstemmed | Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis |
title_short | Antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis |
title_sort | antihypertensive medications are associated with the risk of kidney and bladder cancer: a systematic review and meta-analysis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053620/ https://www.ncbi.nlm.nih.gov/pubmed/31968309 http://dx.doi.org/10.18632/aging.102699 |
work_keys_str_mv | AT xieyuxiu antihypertensivemedicationsareassociatedwiththeriskofkidneyandbladdercancerasystematicreviewandmetaanalysis AT xupeng antihypertensivemedicationsareassociatedwiththeriskofkidneyandbladdercancerasystematicreviewandmetaanalysis AT wangmeng antihypertensivemedicationsareassociatedwiththeriskofkidneyandbladdercancerasystematicreviewandmetaanalysis AT zhengyi antihypertensivemedicationsareassociatedwiththeriskofkidneyandbladdercancerasystematicreviewandmetaanalysis AT tiantian antihypertensivemedicationsareassociatedwiththeriskofkidneyandbladdercancerasystematicreviewandmetaanalysis AT yangsi antihypertensivemedicationsareassociatedwiththeriskofkidneyandbladdercancerasystematicreviewandmetaanalysis AT dengyujiao antihypertensivemedicationsareassociatedwiththeriskofkidneyandbladdercancerasystematicreviewandmetaanalysis AT wuying antihypertensivemedicationsareassociatedwiththeriskofkidneyandbladdercancerasystematicreviewandmetaanalysis AT zhaizhen antihypertensivemedicationsareassociatedwiththeriskofkidneyandbladdercancerasystematicreviewandmetaanalysis AT haoqian antihypertensivemedicationsareassociatedwiththeriskofkidneyandbladdercancerasystematicreviewandmetaanalysis AT songdingli antihypertensivemedicationsareassociatedwiththeriskofkidneyandbladdercancerasystematicreviewandmetaanalysis AT zhangdai antihypertensivemedicationsareassociatedwiththeriskofkidneyandbladdercancerasystematicreviewandmetaanalysis AT daizhijun antihypertensivemedicationsareassociatedwiththeriskofkidneyandbladdercancerasystematicreviewandmetaanalysis |