PIK3CA gene mutations in the helical domain correlate with high tumor mutation burden and poor prognosis in metastatic breast carcinomas with late-line therapies

Nearly half of metastatic breast cancers (MBC) have genetic aberrations in the PI3K/AKT pathway. To investigate the distinct effect of these aberrations on MBC, 193 MBC patients who progressed after the early line (≤2) salvage treatment voluntarily received next generation sequencing (NGS) for a pan...

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Detalles Bibliográficos
Autores principales: Tang, Yu, Li, Jing, Xie, Ning, Yang, Xiaohong, Liu, Liping, Wu, Hui, Tian, Can, He, Ying, Wang, Xiao, He, Qiongzhi, Hu, Zhe-Yu, Ouyang, Quchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053638/
https://www.ncbi.nlm.nih.gov/pubmed/31980592
http://dx.doi.org/10.18632/aging.102701

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