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Preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer

INTRODUCTION: Prognostic nutritional index (PNI) reflects the nutritional and immunologic status of the patients. The clinical application of PNI is already well-known in various kinds of solid tumors. However, there is no study investigating the relationship between PNI and oncological outcome of t...

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Autores principales: Yoo, Young Jin, Kang, Chang Moo, Choi, Munseok, Rho, Seung Yoon, Hwang, Ho Kyung, Lee, Woo Jung, Kim, Eun Wha, Lee, Jin Ae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053754/
https://www.ncbi.nlm.nih.gov/pubmed/32126069
http://dx.doi.org/10.1371/journal.pone.0229597
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author Yoo, Young Jin
Kang, Chang Moo
Choi, Munseok
Rho, Seung Yoon
Hwang, Ho Kyung
Lee, Woo Jung
Kim, Eun Wha
Lee, Jin Ae
author_facet Yoo, Young Jin
Kang, Chang Moo
Choi, Munseok
Rho, Seung Yoon
Hwang, Ho Kyung
Lee, Woo Jung
Kim, Eun Wha
Lee, Jin Ae
author_sort Yoo, Young Jin
collection PubMed
description INTRODUCTION: Prognostic nutritional index (PNI) reflects the nutritional and immunologic status of the patients. The clinical application of PNI is already well-known in various kinds of solid tumors. However, there is no study investigating the relationship between PNI and oncological outcome of the resected ampulla of Vater (AoV) cancer. MATERIALS AND METHODS: From January 2005 to December 2012, the medical records of patients who underwent pancreaticoduodenectomy for pathologically confirmed AoV cancer were retrospectively reviewed. Long-term oncological outcomes were compared according to the preoperative PNI value. RESULT: A total of 118 patients were enrolled in this study. The preoperative PNI was 46.13±6.63, while the mean disease-free survival was 43.88 months and the mean disease-specific survival was 55.3 months. In the multivariate Cox analysis, initial CA19-9 (p = 0.0399), lymphovascular invasion (p = 0.0031), AJCC 8(th) N-stage (p = 0.0018), and preoperative PNI (p = 0.0081) were identified as significant prognostic factors for resected AoV cancer. The disease-specific survival was better in the high preoperative PNI group (≤48.85: 40.77 months vs. >48.85: 68.05 months, p = 0.0015). A highly accurate nomogram was developed based on four clinical components to predict the 1, 3, and 5-year disease-specific survival probability (C-index 0.8169, 0.8426, and 0.8233, respectively). CONCLUSION: In resected AoV cancer, preoperative PNI can play a significant role as an independent prognostic factor for predicting disease-specific survival.
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spelling pubmed-70537542020-03-12 Preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer Yoo, Young Jin Kang, Chang Moo Choi, Munseok Rho, Seung Yoon Hwang, Ho Kyung Lee, Woo Jung Kim, Eun Wha Lee, Jin Ae PLoS One Research Article INTRODUCTION: Prognostic nutritional index (PNI) reflects the nutritional and immunologic status of the patients. The clinical application of PNI is already well-known in various kinds of solid tumors. However, there is no study investigating the relationship between PNI and oncological outcome of the resected ampulla of Vater (AoV) cancer. MATERIALS AND METHODS: From January 2005 to December 2012, the medical records of patients who underwent pancreaticoduodenectomy for pathologically confirmed AoV cancer were retrospectively reviewed. Long-term oncological outcomes were compared according to the preoperative PNI value. RESULT: A total of 118 patients were enrolled in this study. The preoperative PNI was 46.13±6.63, while the mean disease-free survival was 43.88 months and the mean disease-specific survival was 55.3 months. In the multivariate Cox analysis, initial CA19-9 (p = 0.0399), lymphovascular invasion (p = 0.0031), AJCC 8(th) N-stage (p = 0.0018), and preoperative PNI (p = 0.0081) were identified as significant prognostic factors for resected AoV cancer. The disease-specific survival was better in the high preoperative PNI group (≤48.85: 40.77 months vs. >48.85: 68.05 months, p = 0.0015). A highly accurate nomogram was developed based on four clinical components to predict the 1, 3, and 5-year disease-specific survival probability (C-index 0.8169, 0.8426, and 0.8233, respectively). CONCLUSION: In resected AoV cancer, preoperative PNI can play a significant role as an independent prognostic factor for predicting disease-specific survival. Public Library of Science 2020-03-03 /pmc/articles/PMC7053754/ /pubmed/32126069 http://dx.doi.org/10.1371/journal.pone.0229597 Text en © 2020 Yoo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yoo, Young Jin
Kang, Chang Moo
Choi, Munseok
Rho, Seung Yoon
Hwang, Ho Kyung
Lee, Woo Jung
Kim, Eun Wha
Lee, Jin Ae
Preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer
title Preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer
title_full Preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer
title_fullStr Preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer
title_full_unstemmed Preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer
title_short Preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer
title_sort preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of vater cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053754/
https://www.ncbi.nlm.nih.gov/pubmed/32126069
http://dx.doi.org/10.1371/journal.pone.0229597
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