The Stiff People: Two Rare Cases of Stiff-person Syndrome

Stiff-person syndrome (SPS) is a rare disorder that affects the central nervous system and is characterized by progressive muscle stiffness, rigidity, and spasm of axial and limb muscles. The syndrome is caused by a lack of gamma aminobutyric acid (GABA), which occurs because of antibodies against g...

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Detalles Bibliográficos
Autores principales: Siddiqui, Muhammad Z, Tohid, Hassaan, Brown, Rebecca, Qazi, Samia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2017
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053798/
https://www.ncbi.nlm.nih.gov/pubmed/32175215
http://dx.doi.org/10.7759/cureus.1602
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author Siddiqui, Muhammad Z
Tohid, Hassaan
Brown, Rebecca
Qazi, Samia
author_facet Siddiqui, Muhammad Z
Tohid, Hassaan
Brown, Rebecca
Qazi, Samia
author_sort Siddiqui, Muhammad Z
collection PubMed
description Stiff-person syndrome (SPS) is a rare disorder that affects the central nervous system and is characterized by progressive muscle stiffness, rigidity, and spasm of axial and limb muscles. The syndrome is caused by a lack of gamma aminobutyric acid (GABA), which occurs because of antibodies against glutamic acid decarboxylase (GAD), an essential enzyme for GABA synthesis. Hence, the patients present with increased muscular activity. In this article, we will discuss two case studies of stiff-person syndrome.
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spelling pubmed-70537982020-03-13 The Stiff People: Two Rare Cases of Stiff-person Syndrome Siddiqui, Muhammad Z Tohid, Hassaan Brown, Rebecca Qazi, Samia Cureus Neurology Stiff-person syndrome (SPS) is a rare disorder that affects the central nervous system and is characterized by progressive muscle stiffness, rigidity, and spasm of axial and limb muscles. The syndrome is caused by a lack of gamma aminobutyric acid (GABA), which occurs because of antibodies against glutamic acid decarboxylase (GAD), an essential enzyme for GABA synthesis. Hence, the patients present with increased muscular activity. In this article, we will discuss two case studies of stiff-person syndrome. Cureus 2017-08-23 /pmc/articles/PMC7053798/ /pubmed/32175215 http://dx.doi.org/10.7759/cureus.1602 Text en Copyright © 2017, Siddiqui et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Siddiqui, Muhammad Z
Tohid, Hassaan
Brown, Rebecca
Qazi, Samia
The Stiff People: Two Rare Cases of Stiff-person Syndrome
title The Stiff People: Two Rare Cases of Stiff-person Syndrome
title_full The Stiff People: Two Rare Cases of Stiff-person Syndrome
title_fullStr The Stiff People: Two Rare Cases of Stiff-person Syndrome
title_full_unstemmed The Stiff People: Two Rare Cases of Stiff-person Syndrome
title_short The Stiff People: Two Rare Cases of Stiff-person Syndrome
title_sort stiff people: two rare cases of stiff-person syndrome
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053798/
https://www.ncbi.nlm.nih.gov/pubmed/32175215
http://dx.doi.org/10.7759/cureus.1602
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