ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesin(STAG1) from WAPL

Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL. Although WAPL limits cohesin’s chromatin residence time to minutes, it has been reported tha...

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Detalles Bibliográficos
Autores principales: Wutz, Gordana, Ladurner, Rene, St Hilaire, Brian Glenn, Stocsits, Roman R, Nagasaka, Kota, Pignard, Benoit, Sanborn, Adrian, Tang, Wen, Várnai, Csilla, Ivanov, Miroslav P, Schoenfelder, Stefan, van der Lelij, Petra, Huang, Xingfan, Dürnberger, Gerhard, Roitinger, Elisabeth, Mechtler, Karl, Davidson, Iain Finley, Fraser, Peter, Lieberman-Aiden, Erez, Peters, Jan-Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054000/
https://www.ncbi.nlm.nih.gov/pubmed/32065581
http://dx.doi.org/10.7554/eLife.52091

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