A New Polygenic Model for Nonfamilial Colorectal Cancer Inheritance Based on the Genetic Architecture of the Azoxymethane-Induced Mouse Model

The azoxymethane model of colorectal cancer (CRC) was used to gain insights into the genetic heterogeneity of nonfamilial CRC. We observed significant differences in susceptibility parameters across 40 mouse inbred strains, with 6 new and 18 of 24 previously identified mouse CRC modifier alleles det...

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Detalles Bibliográficos
Autores principales: Bissahoyo, Anika C., Xie, Yuying, Yang, Lynda, Pearsall, R. Scott, Lee, Daekee, Elliott, Rosemary W., Demant, Peter, McMillan, Leonard, Pardo-Manuel de Villena, Fernando, Angel, Joe M., Threadgill, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2020
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054011/
https://www.ncbi.nlm.nih.gov/pubmed/31879319
http://dx.doi.org/10.1534/genetics.119.302833

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