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Constituents and Metabolites of a French Oak Wood Extract (Robuvit(®)) in Serum and Blood Cell Samples of Women Undergoing Hysterectomy

Ellagitannins are signature constituents of oak wood and their consumption has been associated with various health benefits. In vivo, they undergo metabolic degradation including gut microbial metabolism yielding urolithins. Only limited data is available about compounds being present in blood after...

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Autores principales: Volpp, Linda, Ferianec, Vladimír, Ježovičová, Miriam, Ďuračková, Zdeňka, Scherf-Clavel, Oliver, Högger, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054277/
https://www.ncbi.nlm.nih.gov/pubmed/32174825
http://dx.doi.org/10.3389/fphar.2020.00074
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author Volpp, Linda
Ferianec, Vladimír
Ježovičová, Miriam
Ďuračková, Zdeňka
Scherf-Clavel, Oliver
Högger, Petra
author_facet Volpp, Linda
Ferianec, Vladimír
Ježovičová, Miriam
Ďuračková, Zdeňka
Scherf-Clavel, Oliver
Högger, Petra
author_sort Volpp, Linda
collection PubMed
description Ellagitannins are signature constituents of oak wood and their consumption has been associated with various health benefits. In vivo, they undergo metabolic degradation including gut microbial metabolism yielding urolithins. Only limited data is available about compounds being present in blood after intake of an extract from French oak wood, Robuvit(®). In the course of a randomized, double-blind, controlled clinical investigation, 66 patients undergoing hysterectomy received placebo or 300 mg Robuvit(®) per day before and over 8 weeks after surgery. Serum and blood cell samples were analyzed by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The number of urolithin producers and the urolithin levels increased after intake of Robuvit(®). In serum samples, the median concentration of urolithin A was 14.0 ng/ml [interquartile range (IQR) 57.4] after 8 weeks. Urolithin B was determined at 22.3 ng/ml (IQR 12.6), urolithin C at 2.66 ng/ml (IQR 2.08). In blood cells, lower concentrations and only urolithins A and B were detected. A statistically significant association of lower post-surgical pain scores with metabotype A was detected (p < 0.05). To conclude, supplementation with French oak wood extract raised urolithin generation in patients and suggested health advantages for urolithin-producers.
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spelling pubmed-70542772020-03-13 Constituents and Metabolites of a French Oak Wood Extract (Robuvit(®)) in Serum and Blood Cell Samples of Women Undergoing Hysterectomy Volpp, Linda Ferianec, Vladimír Ježovičová, Miriam Ďuračková, Zdeňka Scherf-Clavel, Oliver Högger, Petra Front Pharmacol Pharmacology Ellagitannins are signature constituents of oak wood and their consumption has been associated with various health benefits. In vivo, they undergo metabolic degradation including gut microbial metabolism yielding urolithins. Only limited data is available about compounds being present in blood after intake of an extract from French oak wood, Robuvit(®). In the course of a randomized, double-blind, controlled clinical investigation, 66 patients undergoing hysterectomy received placebo or 300 mg Robuvit(®) per day before and over 8 weeks after surgery. Serum and blood cell samples were analyzed by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The number of urolithin producers and the urolithin levels increased after intake of Robuvit(®). In serum samples, the median concentration of urolithin A was 14.0 ng/ml [interquartile range (IQR) 57.4] after 8 weeks. Urolithin B was determined at 22.3 ng/ml (IQR 12.6), urolithin C at 2.66 ng/ml (IQR 2.08). In blood cells, lower concentrations and only urolithins A and B were detected. A statistically significant association of lower post-surgical pain scores with metabotype A was detected (p < 0.05). To conclude, supplementation with French oak wood extract raised urolithin generation in patients and suggested health advantages for urolithin-producers. Frontiers Media S.A. 2020-02-26 /pmc/articles/PMC7054277/ /pubmed/32174825 http://dx.doi.org/10.3389/fphar.2020.00074 Text en Copyright © 2020 Volpp, Ferianec, Ježovičová, Ďuračková, Scherf-Clavel and Högger http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Volpp, Linda
Ferianec, Vladimír
Ježovičová, Miriam
Ďuračková, Zdeňka
Scherf-Clavel, Oliver
Högger, Petra
Constituents and Metabolites of a French Oak Wood Extract (Robuvit(®)) in Serum and Blood Cell Samples of Women Undergoing Hysterectomy
title Constituents and Metabolites of a French Oak Wood Extract (Robuvit(®)) in Serum and Blood Cell Samples of Women Undergoing Hysterectomy
title_full Constituents and Metabolites of a French Oak Wood Extract (Robuvit(®)) in Serum and Blood Cell Samples of Women Undergoing Hysterectomy
title_fullStr Constituents and Metabolites of a French Oak Wood Extract (Robuvit(®)) in Serum and Blood Cell Samples of Women Undergoing Hysterectomy
title_full_unstemmed Constituents and Metabolites of a French Oak Wood Extract (Robuvit(®)) in Serum and Blood Cell Samples of Women Undergoing Hysterectomy
title_short Constituents and Metabolites of a French Oak Wood Extract (Robuvit(®)) in Serum and Blood Cell Samples of Women Undergoing Hysterectomy
title_sort constituents and metabolites of a french oak wood extract (robuvit(®)) in serum and blood cell samples of women undergoing hysterectomy
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054277/
https://www.ncbi.nlm.nih.gov/pubmed/32174825
http://dx.doi.org/10.3389/fphar.2020.00074
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