Drug responses are conserved across patient-derived xenograft models of melanoma leading to identification of novel drug combination therapies

BACKGROUND: Patient-derived xenograft (PDX) mouse tumour models can predict response to therapy in patients. Predictions made from PDX cultures (PDXC) would allow for more rapid and comprehensive evaluation of potential treatment options for patients, including drug combinations. METHODS: We develop...

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Detalles Bibliográficos
Autores principales: Ice, Ryan J., Chen, Michelle, Sidorov, Max, Le Ho, Tam, Woo, Rinette W. L., Rodriguez-Brotons, Aida, Luu, Tri, Jian, Damon, Kim, Kevin B., Leong, Stanley P., Kim, HanKyul, Kim, Angela, Stone, Des, Nazarian, Ari, Oh, Alyssia, Tranah, Gregory J., Nosrati, Mehdi, de Semir, David, Dar, Altaf A., Chang, Stephen, Desprez, Pierre-Yves, Kashani-Sabet, Mohammed, Soroceanu, Liliana, McAllister, Sean D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054294/
https://www.ncbi.nlm.nih.gov/pubmed/31857724
http://dx.doi.org/10.1038/s41416-019-0696-y

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