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The roles of RNA in DNA double-strand break repair
Effective DNA repair is essential for cell survival: a failure to correctly repair damage leads to the accumulation of mutations and is the driving force for carcinogenesis. Multiple pathways have evolved to protect against both intrinsic and extrinsic genotoxic events, and recent developments have...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054366/ https://www.ncbi.nlm.nih.gov/pubmed/31894141 http://dx.doi.org/10.1038/s41416-019-0624-1 |
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author | Bader, Aldo S. Hawley, Ben R. Wilczynska, Ania Bushell, Martin |
author_facet | Bader, Aldo S. Hawley, Ben R. Wilczynska, Ania Bushell, Martin |
author_sort | Bader, Aldo S. |
collection | PubMed |
description | Effective DNA repair is essential for cell survival: a failure to correctly repair damage leads to the accumulation of mutations and is the driving force for carcinogenesis. Multiple pathways have evolved to protect against both intrinsic and extrinsic genotoxic events, and recent developments have highlighted an unforeseen critical role for RNA in ensuring genome stability. It is currently unclear exactly how RNA molecules participate in the repair pathways, although many models have been proposed and it is possible that RNA acts in diverse ways to facilitate DNA repair. A number of well-documented DNA repair factors have been described to have RNA-binding capacities and, moreover, screens investigating DNA-damage repair mechanisms have identified RNA-binding proteins as a major group of novel factors involved in DNA repair. In this review, we integrate some of these datasets to identify commonalities that might highlight novel and interesting factors for future investigations. This emerging role for RNA opens up a new dimension in the field of DNA repair; we discuss its impact on our current understanding of DNA repair processes and consider how it might influence cancer progression. |
format | Online Article Text |
id | pubmed-7054366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70543662020-03-06 The roles of RNA in DNA double-strand break repair Bader, Aldo S. Hawley, Ben R. Wilczynska, Ania Bushell, Martin Br J Cancer Review Article Effective DNA repair is essential for cell survival: a failure to correctly repair damage leads to the accumulation of mutations and is the driving force for carcinogenesis. Multiple pathways have evolved to protect against both intrinsic and extrinsic genotoxic events, and recent developments have highlighted an unforeseen critical role for RNA in ensuring genome stability. It is currently unclear exactly how RNA molecules participate in the repair pathways, although many models have been proposed and it is possible that RNA acts in diverse ways to facilitate DNA repair. A number of well-documented DNA repair factors have been described to have RNA-binding capacities and, moreover, screens investigating DNA-damage repair mechanisms have identified RNA-binding proteins as a major group of novel factors involved in DNA repair. In this review, we integrate some of these datasets to identify commonalities that might highlight novel and interesting factors for future investigations. This emerging role for RNA opens up a new dimension in the field of DNA repair; we discuss its impact on our current understanding of DNA repair processes and consider how it might influence cancer progression. Nature Publishing Group UK 2020-01-02 2020-03-03 /pmc/articles/PMC7054366/ /pubmed/31894141 http://dx.doi.org/10.1038/s41416-019-0624-1 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Bader, Aldo S. Hawley, Ben R. Wilczynska, Ania Bushell, Martin The roles of RNA in DNA double-strand break repair |
title | The roles of RNA in DNA double-strand break repair |
title_full | The roles of RNA in DNA double-strand break repair |
title_fullStr | The roles of RNA in DNA double-strand break repair |
title_full_unstemmed | The roles of RNA in DNA double-strand break repair |
title_short | The roles of RNA in DNA double-strand break repair |
title_sort | roles of rna in dna double-strand break repair |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054366/ https://www.ncbi.nlm.nih.gov/pubmed/31894141 http://dx.doi.org/10.1038/s41416-019-0624-1 |
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