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Functional Consequences of PDK4 Deficiency in Doberman Pinscher Fibroblasts
A splice site mutation in the canine pyruvate dehydrogenase kinase 4 (PDK4) gene has been shown to be associated with the development of dilated cardiomyopathy (DCM) in Doberman Pinchers (DPs). Subsequent studies have successfully demonstrated the use of dermal fibroblasts isolated from DPs as model...
Autores principales: | Bolfer, Luiz, Estrada, Amara H., Larkin, Chelsea, Conlon, Thomas J., Lourenco, Francisco, Taggart, Kathryn, Suzuki-Hatano, Silveli, Pacak, Christina A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054397/ https://www.ncbi.nlm.nih.gov/pubmed/32127618 http://dx.doi.org/10.1038/s41598-020-60879-6 |
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