Cargando…

In vitro and in vivo pharmacokinetic characterization of LMT-28 as a novel small molecular interleukin-6 inhibitor

OBJECTIVE: Interleukin-6 (IL-6) is a T cell-derived B cell stimulating factor which plays an important role in inflammatory diseases. In this study, the pharmacokinetic properties of LMT-28 including physicochemical property, in vitro liver microsomal stability and an in vivo pharmacokinetic study u...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahn, Sung-Hoon, Heo, Tae-Hwe, Jun, Hyun-Sik, Choi, Yongseok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Asian-Australasian Association of Animal Production Societies (AAAP) and Korean Society of Animal Science and Technology (KSAST) 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054612/ https://www.ncbi.nlm.nih.gov/pubmed/31480155 http://dx.doi.org/10.5713/ajas.19.0463

Ejemplares similares

Self-Trained LMT for Semisupervised Learning
por: Fazakis, Nikos, et al.
Publicado: (2016)

Amelioration of Cerebral Ischemic Injury by a Synthetic Seco-nucleoside LMT497
por: Ryu, Sangwoo, et al.
Publicado: (2015)

Getting to Phase 3: an Interview with Virginia S. Cowen, PhD, LMT
por: Kennedy, Ann Blair
Publicado: (2017)

Striving to Make Massage Therapy Accessible to Older Adults: an Interview with Niki Munk, PhD, LMT
por: Kennedy, Ann Blair
Publicado: (2018)

Lactobacillus plantarum LMT1-48 exerts anti-obesity effect in high-fat diet-induced obese mice by regulating expression of lipogenic genes
por: Choi, Woo Jin, et al.
Publicado: (2020)

Effect of Lactobacillus plantarum LMT1-48 on Body Fat in Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Trial
por: Sohn, Minji, et al.
Publicado: (2023)

A GP130-Targeting Small Molecule, LMT-28, Reduces LPS-Induced Bone Resorption around Implants in Diabetic Models by Inhibiting IL-6/GP130/JAK2/STAT3 Signaling
por: Liu, Qi-qi, et al.
Publicado: (2023)

Plant-Derived Purification, Chemical Synthesis, and In Vitro/In Vivo Evaluation of a Resveratrol Dimer, Viniferin, as an HCV Replication Inhibitor
por: Lee, Sungjin, et al.
Publicado: (2019)

LMT(db): A comprehensive transcriptome database for climate-resilient, nutritionally rich little millet (Panicum sumatrense)
por: Shekhar, Shweta, et al.
Publicado: (2023)

Bolstering the Three Pillars of the Essential Architecture of the Massage Therapy Profession: an Interview with Glenn M. Hymel, EdD, LMT
por: Kennedy, Ann Blair
Publicado: (2018)

Pravastatin and Sarpogrelate Synergistically Ameliorate Atherosclerosis in LDLr-Knockout Mice
por: Park, Kyung-Yeon, et al.
Publicado: (2016)

Bazedoxifene, a GP130 Inhibitor, Modulates EMT Signaling and Exhibits Antitumor Effects in HPV-Positive Cervical Cancer
por: Kim, Leekyung, et al.
Publicado: (2021)

The in vitro metabolism and in vivo pharmacokinetics of the bacterial β-glucuronidase inhibitor UNC10201652
por: Kerins, Anna, et al.
Publicado: (2022)

Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer
por: Heo, Tae-Hwe, et al.
Publicado: (2016)

Effects of dacomitinib on the pharmacokinetics of poziotinib in vivo and in vitro
por: Ji, Weiping, et al.
Publicado: (2021)

Study on In Vitro Metabolism and In Vivo Pharmacokinetics of Beauvericin
por: Yuan, Yu, et al.
Publicado: (2022)

Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies
por: Wempe, Michael F, et al.
Publicado: (2012)

Evaluation of the Pharmacokinetics of the Pancreastatin Inhibitor PSTi8 Peptide in Rats: Integration of In Vitro and In Vivo Findings
por: Valicherla, Guru R., et al.
Publicado: (2022)

Identification of small molecule inhibitors of Interleukin-18
por: Krumm, Brian, et al.
Publicado: (2017)

Inhibitory Effect of Imperatorin on the Pharmacokinetics of Diazepam In Vitro and In Vivo
por: Zhou, Yunfang, et al.
Publicado: (2020)

Effects of avitinib on the pharmacokinetics of osimertinib in vitro and in vivo in rats
por: Wu, Qingjun, et al.
Publicado: (2020)

In vitro and in vivo human metabolism and pharmacokinetics of S‐ and R‐praziquantel
por: Kapungu, Nyasha Nicole, et al.
Publicado: (2020)

Pharmacokinetics of PEGylated Gold Nanoparticles: In Vitro—In Vivo Correlation
por: Dubaj, Tibor, et al.
Publicado: (2022)

Pretreatment neutrophil‐lymphocyte ratio is not a significant prognostic factor in epidermal growth factor receptor‐mutant non‐small cell lung cancer patients treated with tyrosine kinase inhibitors
por: Sim, Sung Hoon, et al.
Publicado: (2015)

Correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among HCV patients in Yazd, Iran
por: Moghimi, Mansour, et al.
Publicado: (2019)

Analysis of Time-Dependent Pharmacokinetics Using In Vitro–In Vivo Extrapolation and Physiologically Based Pharmacokinetic Modeling
por: Kim, Min-Chang, et al.
Publicado: (2022)

Antibodies to interleukin 2. Effects on immune responses in vitro and in vivo
Publicado: (1984)

In vitro and in vivo evaluation of hypothermia on pharmacokinetics and pharmacodynamics of nimodipine in rabbits
por: Fei, Yu-xing, et al.
Publicado: (2017)

In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease
por: Fitzpatrick, Rikki L., et al.
Publicado: (2018)

In Vitro, In Silico, and In Vivo Assessments of Pharmacokinetic Properties of ZM241385
por: Byeon, Jin-Ju, et al.
Publicado: (2020)

Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation
por: Hines, David E., et al.
Publicado: (2022)

Effects of bergapten on the pharmacokinetics of macitentan in rats both in vitro and in vivo
por: Xu, Jia, et al.
Publicado: (2023)

Normalization of the levels of inflammatory molecules in Mycobacterium smegmatis-infected U937 cells by fibrate pretreatment
por: Kim, Sung-Jo, et al.
Publicado: (2014)

Machine Learning-Based Approach to Developing Potent EGFR Inhibitors for Breast Cancer—Design, Synthesis, and In Vitro Evaluation
por: Nada, Hossam, et al.
Publicado: (2023)

ERK inhibitor ASN007 effectively overcomes acquired resistance to EGFR inhibitor in non‐small cell lung cancer
por: Ku, Bo Mi, et al.
Publicado: (2022)

A Small Compound KJ-28d Enhances the Sensitivity of Non-Small Cell Lung Cancer to Radio- and Chemotherapy
por: Ryu, Hwani, et al.
Publicado: (2019)

Peripheral lymphocyte count as a surrogate marker of immune checkpoint inhibitor therapy outcomes in patients with non-small-cell lung cancer
por: Lee, Ye Jin, et al.
Publicado: (2022)

Anticipatory governance for newcomers: lessons learned from the UK, the Netherlands, Finland, and Korea
por: Heo, Kyungmoo, et al.
Publicado: (2021)

Interleukin-28B polymorphisms and hepatitis C virus clearance
por: Chayama, Kazuaki, et al.
Publicado: (2013)

LMT USV Toolbox, a Novel Methodological Approach to Place Mouse Ultrasonic Vocalizations in Their Behavioral Contexts—A Study in Female and Male C57BL/6J Mice and in Shank3 Mutant Females
por: de Chaumont, Fabrice, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_uo6n15r57pv52m70bk81k98mjt