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Npl3 stabilizes R‐loops at telomeres to prevent accelerated replicative senescence

Telomere shortening rates must be regulated to prevent premature replicative senescence. TERRA R‐loops become stabilized at critically short telomeres to promote their elongation through homology‐directed repair (HDR), thereby counteracting senescence onset. Using a non‐bias proteomic approach to de...

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Detalles Bibliográficos
Autores principales: Pérez‐Martínez, Lara, Öztürk, Merve, Butter, Falk, Luke, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054685/
https://www.ncbi.nlm.nih.gov/pubmed/32026548
http://dx.doi.org/10.15252/embr.201949087

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