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Types of acute phase reactants and their importance in vaccination
Vaccines are considered to be one of the most cost-effective life-saving interventions in human history. The body's inflammatory response to vaccines has both desired effects (immune response), undesired effects [(acute phase reactions (APRs)] and trade-offs. Trade-offs are more potent immune r...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054702/ https://www.ncbi.nlm.nih.gov/pubmed/32190302 http://dx.doi.org/10.3892/br.2020.1276 |
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author | Khalil, Rafaat H. Al-Humadi, Nabil |
author_facet | Khalil, Rafaat H. Al-Humadi, Nabil |
author_sort | Khalil, Rafaat H. |
collection | PubMed |
description | Vaccines are considered to be one of the most cost-effective life-saving interventions in human history. The body's inflammatory response to vaccines has both desired effects (immune response), undesired effects [(acute phase reactions (APRs)] and trade-offs. Trade-offs are more potent immune responses which may be potentially difficult to separate from potent acute phase reactions. Thus, studying acute phase proteins (APPs) during vaccination may aid our understanding of APRs and homeostatic changes which can result from inflammatory responses. Depending on the severity of the response in humans, these reactions can be classified as major, moderate or minor. In this review, types of APPs and their importance in vaccination will be discussed. |
format | Online Article Text |
id | pubmed-7054702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-70547022020-03-18 Types of acute phase reactants and their importance in vaccination Khalil, Rafaat H. Al-Humadi, Nabil Biomed Rep Review Vaccines are considered to be one of the most cost-effective life-saving interventions in human history. The body's inflammatory response to vaccines has both desired effects (immune response), undesired effects [(acute phase reactions (APRs)] and trade-offs. Trade-offs are more potent immune responses which may be potentially difficult to separate from potent acute phase reactions. Thus, studying acute phase proteins (APPs) during vaccination may aid our understanding of APRs and homeostatic changes which can result from inflammatory responses. Depending on the severity of the response in humans, these reactions can be classified as major, moderate or minor. In this review, types of APPs and their importance in vaccination will be discussed. D.A. Spandidos 2020-04 2020-02-11 /pmc/articles/PMC7054702/ /pubmed/32190302 http://dx.doi.org/10.3892/br.2020.1276 Text en Copyright: © Khalil et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Khalil, Rafaat H. Al-Humadi, Nabil Types of acute phase reactants and their importance in vaccination |
title | Types of acute phase reactants and their importance in vaccination |
title_full | Types of acute phase reactants and their importance in vaccination |
title_fullStr | Types of acute phase reactants and their importance in vaccination |
title_full_unstemmed | Types of acute phase reactants and their importance in vaccination |
title_short | Types of acute phase reactants and their importance in vaccination |
title_sort | types of acute phase reactants and their importance in vaccination |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054702/ https://www.ncbi.nlm.nih.gov/pubmed/32190302 http://dx.doi.org/10.3892/br.2020.1276 |
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