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Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes
BACKGROUND: Serum calcification propensity can be monitored using the maturation time of calciprotein particles in serum (T(50) test). A shorter T(50) indicates greater propensity to calcify; this is an independent determinant of cardiovascular disease. As the intraperitoneal (IP) route of insulin a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054733/ https://www.ncbi.nlm.nih.gov/pubmed/32166012 http://dx.doi.org/10.1177/2042018820908456 |
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author | van Dijk, Peter R. Waanders, Femke Pasch, Andreas Logtenberg, Susan J. J. Vriesendorp, Titia Groenier, Klaas H. Hillebrands, Jan-Luuk Kleefstra, Nanno Gans, Rijk O. B. van Goor, Harry Bilo, Henk J.G. |
author_facet | van Dijk, Peter R. Waanders, Femke Pasch, Andreas Logtenberg, Susan J. J. Vriesendorp, Titia Groenier, Klaas H. Hillebrands, Jan-Luuk Kleefstra, Nanno Gans, Rijk O. B. van Goor, Harry Bilo, Henk J.G. |
author_sort | van Dijk, Peter R. |
collection | PubMed |
description | BACKGROUND: Serum calcification propensity can be monitored using the maturation time of calciprotein particles in serum (T(50) test). A shorter T(50) indicates greater propensity to calcify; this is an independent determinant of cardiovascular disease. As the intraperitoneal (IP) route of insulin administration mimics the physiology more than the subcutaneous (SC) route in persons with type 1 diabetes (T1DM), we hypothesized that IP insulin influences determinants of calcium propensity and therefore result in a longer T(50) than SC insulin administration. METHODS: Prospective, observational case-control study. Measurements were performed at baseline and at 26 weeks in age and gender matched persons with T1DM. RESULTS: A total of 181 persons, 39 (21.5%) of which used IP and 142 (78.5%) SC insulin were analysed. Baseline T(50) was 356 (45) minutes. The geometric mean T(50) significantly differed between both treatment groups: 367 [95% confidence interval (CI) 357, 376] for the IP group and 352 (95% CI 347, 357) for the SC group with a difference of –15 (95% CI –25, –4) minutes, in favour of IP treatment. In multivariable analyses, the IP route of insulin administration had a positive relation on T(50) concentrations while higher age, triglycerides and phosphate concentrations had an inverse relation. CONCLUSION: Among persons with T1DM, IP insulin administration results in a more favourable calcification propensity time then SC insulin. It has yet to be shown if this observation translates into improved cardiovascular outcomes. |
format | Online Article Text |
id | pubmed-7054733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-70547332020-03-12 Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes van Dijk, Peter R. Waanders, Femke Pasch, Andreas Logtenberg, Susan J. J. Vriesendorp, Titia Groenier, Klaas H. Hillebrands, Jan-Luuk Kleefstra, Nanno Gans, Rijk O. B. van Goor, Harry Bilo, Henk J.G. Ther Adv Endocrinol Metab Original Research BACKGROUND: Serum calcification propensity can be monitored using the maturation time of calciprotein particles in serum (T(50) test). A shorter T(50) indicates greater propensity to calcify; this is an independent determinant of cardiovascular disease. As the intraperitoneal (IP) route of insulin administration mimics the physiology more than the subcutaneous (SC) route in persons with type 1 diabetes (T1DM), we hypothesized that IP insulin influences determinants of calcium propensity and therefore result in a longer T(50) than SC insulin administration. METHODS: Prospective, observational case-control study. Measurements were performed at baseline and at 26 weeks in age and gender matched persons with T1DM. RESULTS: A total of 181 persons, 39 (21.5%) of which used IP and 142 (78.5%) SC insulin were analysed. Baseline T(50) was 356 (45) minutes. The geometric mean T(50) significantly differed between both treatment groups: 367 [95% confidence interval (CI) 357, 376] for the IP group and 352 (95% CI 347, 357) for the SC group with a difference of –15 (95% CI –25, –4) minutes, in favour of IP treatment. In multivariable analyses, the IP route of insulin administration had a positive relation on T(50) concentrations while higher age, triglycerides and phosphate concentrations had an inverse relation. CONCLUSION: Among persons with T1DM, IP insulin administration results in a more favourable calcification propensity time then SC insulin. It has yet to be shown if this observation translates into improved cardiovascular outcomes. SAGE Publications 2020-03-03 /pmc/articles/PMC7054733/ /pubmed/32166012 http://dx.doi.org/10.1177/2042018820908456 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research van Dijk, Peter R. Waanders, Femke Pasch, Andreas Logtenberg, Susan J. J. Vriesendorp, Titia Groenier, Klaas H. Hillebrands, Jan-Luuk Kleefstra, Nanno Gans, Rijk O. B. van Goor, Harry Bilo, Henk J.G. Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes |
title | Favourable serum calcification propensity with intraperitoneal as
compared with subcutaneous insulin administration in type 1
diabetes |
title_full | Favourable serum calcification propensity with intraperitoneal as
compared with subcutaneous insulin administration in type 1
diabetes |
title_fullStr | Favourable serum calcification propensity with intraperitoneal as
compared with subcutaneous insulin administration in type 1
diabetes |
title_full_unstemmed | Favourable serum calcification propensity with intraperitoneal as
compared with subcutaneous insulin administration in type 1
diabetes |
title_short | Favourable serum calcification propensity with intraperitoneal as
compared with subcutaneous insulin administration in type 1
diabetes |
title_sort | favourable serum calcification propensity with intraperitoneal as
compared with subcutaneous insulin administration in type 1
diabetes |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054733/ https://www.ncbi.nlm.nih.gov/pubmed/32166012 http://dx.doi.org/10.1177/2042018820908456 |
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