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Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes

BACKGROUND: Serum calcification propensity can be monitored using the maturation time of calciprotein particles in serum (T(50) test). A shorter T(50) indicates greater propensity to calcify; this is an independent determinant of cardiovascular disease. As the intraperitoneal (IP) route of insulin a...

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Autores principales: van Dijk, Peter R., Waanders, Femke, Pasch, Andreas, Logtenberg, Susan J. J., Vriesendorp, Titia, Groenier, Klaas H., Hillebrands, Jan-Luuk, Kleefstra, Nanno, Gans, Rijk O. B., van Goor, Harry, Bilo, Henk J.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054733/
https://www.ncbi.nlm.nih.gov/pubmed/32166012
http://dx.doi.org/10.1177/2042018820908456
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author van Dijk, Peter R.
Waanders, Femke
Pasch, Andreas
Logtenberg, Susan J. J.
Vriesendorp, Titia
Groenier, Klaas H.
Hillebrands, Jan-Luuk
Kleefstra, Nanno
Gans, Rijk O. B.
van Goor, Harry
Bilo, Henk J.G.
author_facet van Dijk, Peter R.
Waanders, Femke
Pasch, Andreas
Logtenberg, Susan J. J.
Vriesendorp, Titia
Groenier, Klaas H.
Hillebrands, Jan-Luuk
Kleefstra, Nanno
Gans, Rijk O. B.
van Goor, Harry
Bilo, Henk J.G.
author_sort van Dijk, Peter R.
collection PubMed
description BACKGROUND: Serum calcification propensity can be monitored using the maturation time of calciprotein particles in serum (T(50) test). A shorter T(50) indicates greater propensity to calcify; this is an independent determinant of cardiovascular disease. As the intraperitoneal (IP) route of insulin administration mimics the physiology more than the subcutaneous (SC) route in persons with type 1 diabetes (T1DM), we hypothesized that IP insulin influences determinants of calcium propensity and therefore result in a longer T(50) than SC insulin administration. METHODS: Prospective, observational case-control study. Measurements were performed at baseline and at 26 weeks in age and gender matched persons with T1DM. RESULTS: A total of 181 persons, 39 (21.5%) of which used IP and 142 (78.5%) SC insulin were analysed. Baseline T(50) was 356 (45) minutes. The geometric mean T(50) significantly differed between both treatment groups: 367 [95% confidence interval (CI) 357, 376] for the IP group and 352 (95% CI 347, 357) for the SC group with a difference of –15 (95% CI –25, –4) minutes, in favour of IP treatment. In multivariable analyses, the IP route of insulin administration had a positive relation on T(50) concentrations while higher age, triglycerides and phosphate concentrations had an inverse relation. CONCLUSION: Among persons with T1DM, IP insulin administration results in a more favourable calcification propensity time then SC insulin. It has yet to be shown if this observation translates into improved cardiovascular outcomes.
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spelling pubmed-70547332020-03-12 Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes van Dijk, Peter R. Waanders, Femke Pasch, Andreas Logtenberg, Susan J. J. Vriesendorp, Titia Groenier, Klaas H. Hillebrands, Jan-Luuk Kleefstra, Nanno Gans, Rijk O. B. van Goor, Harry Bilo, Henk J.G. Ther Adv Endocrinol Metab Original Research BACKGROUND: Serum calcification propensity can be monitored using the maturation time of calciprotein particles in serum (T(50) test). A shorter T(50) indicates greater propensity to calcify; this is an independent determinant of cardiovascular disease. As the intraperitoneal (IP) route of insulin administration mimics the physiology more than the subcutaneous (SC) route in persons with type 1 diabetes (T1DM), we hypothesized that IP insulin influences determinants of calcium propensity and therefore result in a longer T(50) than SC insulin administration. METHODS: Prospective, observational case-control study. Measurements were performed at baseline and at 26 weeks in age and gender matched persons with T1DM. RESULTS: A total of 181 persons, 39 (21.5%) of which used IP and 142 (78.5%) SC insulin were analysed. Baseline T(50) was 356 (45) minutes. The geometric mean T(50) significantly differed between both treatment groups: 367 [95% confidence interval (CI) 357, 376] for the IP group and 352 (95% CI 347, 357) for the SC group with a difference of –15 (95% CI –25, –4) minutes, in favour of IP treatment. In multivariable analyses, the IP route of insulin administration had a positive relation on T(50) concentrations while higher age, triglycerides and phosphate concentrations had an inverse relation. CONCLUSION: Among persons with T1DM, IP insulin administration results in a more favourable calcification propensity time then SC insulin. It has yet to be shown if this observation translates into improved cardiovascular outcomes. SAGE Publications 2020-03-03 /pmc/articles/PMC7054733/ /pubmed/32166012 http://dx.doi.org/10.1177/2042018820908456 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
van Dijk, Peter R.
Waanders, Femke
Pasch, Andreas
Logtenberg, Susan J. J.
Vriesendorp, Titia
Groenier, Klaas H.
Hillebrands, Jan-Luuk
Kleefstra, Nanno
Gans, Rijk O. B.
van Goor, Harry
Bilo, Henk J.G.
Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes
title Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes
title_full Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes
title_fullStr Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes
title_full_unstemmed Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes
title_short Favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes
title_sort favourable serum calcification propensity with intraperitoneal as compared with subcutaneous insulin administration in type 1 diabetes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054733/
https://www.ncbi.nlm.nih.gov/pubmed/32166012
http://dx.doi.org/10.1177/2042018820908456
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