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Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease

Prion diseases are fatal transmissible neurodegenerative conditions of humans and animals that arise through neurotoxicity induced by PrP misfolding. The cellular and molecular mechanisms of prion-induced neurotoxicity remain undefined. Understanding these processes will underpin therapeutic and con...

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Detalles Bibliográficos
Autores principales:	Thackray, Alana M., Lam, Brian, Shahira Binti Ab Razak, Anisa, Yeo, Giles, Bujdoso, Raymond
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Molecular Bases of Health & Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054746/ https://www.ncbi.nlm.nih.gov/pubmed/32108870 http://dx.doi.org/10.1042/BCJ20190872

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