The Combination of Patient Profiling and Preclinical Studies in a Mouse Model Based on NOD/Scid IL2Rγ (null) Mice Reconstituted With Peripheral Blood Mononuclear Cells From Patients With Ulcerative Colitis May Lead to Stratification of Patients for Treatment With Adalimumab

BACKGROUND: To date, responsiveness to tumor necrosis factor alpha inhibitors in ulcerative colitis (UC) patients is not predictable. This is partially due to a lack of understanding of the underlying inflammatory processes. The aim of this study was to identify immunological subgroups of patients w...

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Detalles Bibliográficos
Autores principales: Jodeleit, Henrika, Caesar, Janina, Villarroel Aguilera, Christina, Sterz, Sebastian, Holdt, Lesca, Beigel, Florian, Stallhofer, Johannes, Breiteneicher, Simone, Bartnik, Eckart, Siebeck, Matthias, Gropp, Roswitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic Science Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054775/
https://www.ncbi.nlm.nih.gov/pubmed/31782956
http://dx.doi.org/10.1093/ibd/izz284

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