Cargando…
Probing the subcellular distribution of phosphatidylinositol reveals a surprising lack at the plasma membrane
The polyphosphoinositides (PPIn) are central regulatory lipids that direct membrane function in eukaryotic cells. Understanding how their synthesis is regulated is crucial to revealing these lipids’ role in health and disease. PPIn are derived from the major structural lipid, phosphatidylinositol (P...
Autores principales: | Zewe, James P., Miller, April M., Sangappa, Sahana, Wills, Rachel C., Goulden, Brady D., Hammond, Gerald R.V. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054989/ https://www.ncbi.nlm.nih.gov/pubmed/32211893 http://dx.doi.org/10.1083/jcb.201906127 |
Ejemplares similares
-
SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes
por: Zewe, James P, et al.
Publicado: (2018) -
Defining the subcellular distribution and metabolic channeling of phosphatidylinositol
por: Pemberton, Joshua G., et al.
Publicado: (2020) -
A high-avidity biosensor reveals plasma membrane PI(3,4)P(2) is predominantly a class I PI3K signaling product
por: Goulden, Brady D., et al.
Publicado: (2019) -
A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi
por: Hammond, Gerald R.V., et al.
Publicado: (2014) -
PI(4,5)P(2) diffuses freely in the plasma membrane even within high-density effector protein complexes
por: Pacheco, Jonathan, et al.
Publicado: (2022)