Heparan sulfate and clusterin: Cleaning squad for extracellular protein degradation

The mechanisms of quality control for extracellular proteins are still poorly understood. In this issue, Itakura et al. (2020. J. Cell. Biol. https://doi.org/10.1083/jcb.201911126) show that upon binding to misfolded proteins, the extracellular chaperone clusterin is internalized via the heparan sul...

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Detalles Bibliográficos
Autores principales: Sánchez-Martín, Pablo, Komatsu, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055003/
https://www.ncbi.nlm.nih.gov/pubmed/32211896
http://dx.doi.org/10.1083/jcb.202001159
Descripción
Sumario:The mechanisms of quality control for extracellular proteins are still poorly understood. In this issue, Itakura et al. (2020. J. Cell. Biol. https://doi.org/10.1083/jcb.201911126) show that upon binding to misfolded proteins, the extracellular chaperone clusterin is internalized via the heparan sulfate receptor to undergo lysosomal degradation.

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