Heparan sulfate and clusterin: Cleaning squad for extracellular protein degradation

The mechanisms of quality control for extracellular proteins are still poorly understood. In this issue, Itakura et al. (2020. J. Cell. Biol. https://doi.org/10.1083/jcb.201911126) show that upon binding to misfolded proteins, the extracellular chaperone clusterin is internalized via the heparan sul...

Descripción completa

Detalles Bibliográficos
Autores principales: Sánchez-Martín, Pablo, Komatsu, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055003/
https://www.ncbi.nlm.nih.gov/pubmed/32211896
http://dx.doi.org/10.1083/jcb.202001159
_version_ 1783503287348101120
author Sánchez-Martín, Pablo
Komatsu, Masaaki
author_facet Sánchez-Martín, Pablo
Komatsu, Masaaki
author_sort Sánchez-Martín, Pablo
collection PubMed
description The mechanisms of quality control for extracellular proteins are still poorly understood. In this issue, Itakura et al. (2020. J. Cell. Biol. https://doi.org/10.1083/jcb.201911126) show that upon binding to misfolded proteins, the extracellular chaperone clusterin is internalized via the heparan sulfate receptor to undergo lysosomal degradation.
format Online
Article
Text
id pubmed-7055003
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-70550032020-09-02 Heparan sulfate and clusterin: Cleaning squad for extracellular protein degradation Sánchez-Martín, Pablo Komatsu, Masaaki J Cell Biol Spotlight The mechanisms of quality control for extracellular proteins are still poorly understood. In this issue, Itakura et al. (2020. J. Cell. Biol. https://doi.org/10.1083/jcb.201911126) show that upon binding to misfolded proteins, the extracellular chaperone clusterin is internalized via the heparan sulfate receptor to undergo lysosomal degradation. Rockefeller University Press 2020-02-20 /pmc/articles/PMC7055003/ /pubmed/32211896 http://dx.doi.org/10.1083/jcb.202001159 Text en © 2020 Sánchez-Martín and Komatsu http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Sánchez-Martín, Pablo
Komatsu, Masaaki
Heparan sulfate and clusterin: Cleaning squad for extracellular protein degradation
title Heparan sulfate and clusterin: Cleaning squad for extracellular protein degradation
title_full Heparan sulfate and clusterin: Cleaning squad for extracellular protein degradation
title_fullStr Heparan sulfate and clusterin: Cleaning squad for extracellular protein degradation
title_full_unstemmed Heparan sulfate and clusterin: Cleaning squad for extracellular protein degradation
title_short Heparan sulfate and clusterin: Cleaning squad for extracellular protein degradation
title_sort heparan sulfate and clusterin: cleaning squad for extracellular protein degradation
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055003/
https://www.ncbi.nlm.nih.gov/pubmed/32211896
http://dx.doi.org/10.1083/jcb.202001159
work_keys_str_mv AT sanchezmartinpablo heparansulfateandclusterincleaningsquadforextracellularproteindegradation
AT komatsumasaaki heparansulfateandclusterincleaningsquadforextracellularproteindegradation

Ejemplares similares