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Five-year cost-effectiveness analysis of the European Fans in Training (EuroFIT) physical activity intervention for men versus no intervention

OBJECTIVES: Increasing physical activity reduces the risk of chronic illness including Type 2 diabetes, cardiovascular disease and certain types of cancer. Lifestyle interventions can increase physical activity but few successfully engage men. This study aims to investigate the 5 year cost-effective...

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Autores principales: Kolovos, Spyros, Finch, Aureliano P., van der Ploeg, Hidde P., van Nassau, Femke, Broulikova, Hana M., Baka, Agni, Treweek, Shaun, Gray, Cindy M., Jelsma, Judith G. M., Bunn, Christopher, Roberts, Glyn C., Silva, Marlene N., Gill, Jason M. R., Røynesdal, Øystein, van Mechelen, Willem, Andersen, Eivind, Hunt, Kate, Wyke, Sally, Bosmans, Judith E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055048/
https://www.ncbi.nlm.nih.gov/pubmed/32131849
http://dx.doi.org/10.1186/s12966-020-00934-7
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author Kolovos, Spyros
Finch, Aureliano P.
van der Ploeg, Hidde P.
van Nassau, Femke
Broulikova, Hana M.
Baka, Agni
Treweek, Shaun
Gray, Cindy M.
Jelsma, Judith G. M.
Bunn, Christopher
Roberts, Glyn C.
Silva, Marlene N.
Gill, Jason M. R.
Røynesdal, Øystein
van Mechelen, Willem
Andersen, Eivind
Hunt, Kate
Wyke, Sally
Bosmans, Judith E.
author_facet Kolovos, Spyros
Finch, Aureliano P.
van der Ploeg, Hidde P.
van Nassau, Femke
Broulikova, Hana M.
Baka, Agni
Treweek, Shaun
Gray, Cindy M.
Jelsma, Judith G. M.
Bunn, Christopher
Roberts, Glyn C.
Silva, Marlene N.
Gill, Jason M. R.
Røynesdal, Øystein
van Mechelen, Willem
Andersen, Eivind
Hunt, Kate
Wyke, Sally
Bosmans, Judith E.
author_sort Kolovos, Spyros
collection PubMed
description OBJECTIVES: Increasing physical activity reduces the risk of chronic illness including Type 2 diabetes, cardiovascular disease and certain types of cancer. Lifestyle interventions can increase physical activity but few successfully engage men. This study aims to investigate the 5 year cost-effectiveness of EuroFIT, a program to improve physical activity tailored specifically for male football (soccer) fans compared to a no intervention comparison group. METHODS: We developed a Markov cohort model in which the impact of improving physical activity on five chronic health conditions (colorectal cancer, Type 2 diabetes, coronary heart disease, stroke and depression) and mortality was modelled. We estimated costs from a societal perspective and expressed benefits as quality adjusted life years (QALYs). We obtained data from a 4-country (England, Netherlands, Portugal and Norway) pragmatic randomised controlled trial evaluating EuroFIT, epidemiological and cohort studies, and meta-analyses. We performed deterministic and probabilistic sensitivity analyses to assess the impact of uncertainty in the model’s parameter values on the cost-effectiveness results. We used Monte Carlo simulations to estimate uncertainty and presented this using cost-effectiveness acceptability curves (CEACs). We tested the robustness of the base case analysis using five scenario analyses. RESULTS: Average costs over 5 years per person receiving EuroFIT were €14,663 and per person receiving no intervention €14,598. Mean QALYs over 5 years were 4.05 per person for EuroFIT and 4.04 for no intervention. Thus, the average incremental cost per person receiving EuroFIT was €65 compared to no intervention, while the average QALY gain was 0.01. This resulted in an ICER of €5206 per QALY gained. CEACs show that the probability of EuroFIT being cost-effective compared to no intervention is 0.53, 0.56 and 0.58 at thresholds of €10,000, €22,000 and €34,000 per QALY gained, respectively. When using a time horizon of 10 years, the results suggest that EuroFIT is more effective and less expensive compared to (i.e. dominant over) no intervention with a probability of cost-effectiveness of 0.63 at a threshold of €22,000 per QALY gained. CONCLUSIONS: We conclude the EuroFIT intervention is not cost-effective compared to no intervention over a period of 5 years from a societal perspective, but is more effective and less expensive (i.e. dominant) after 10 years. We thus suggest that EuroFIT can potentially improve public health in a cost-effective manner in the long term.
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spelling pubmed-70550482020-03-10 Five-year cost-effectiveness analysis of the European Fans in Training (EuroFIT) physical activity intervention for men versus no intervention Kolovos, Spyros Finch, Aureliano P. van der Ploeg, Hidde P. van Nassau, Femke Broulikova, Hana M. Baka, Agni Treweek, Shaun Gray, Cindy M. Jelsma, Judith G. M. Bunn, Christopher Roberts, Glyn C. Silva, Marlene N. Gill, Jason M. R. Røynesdal, Øystein van Mechelen, Willem Andersen, Eivind Hunt, Kate Wyke, Sally Bosmans, Judith E. Int J Behav Nutr Phys Act Research OBJECTIVES: Increasing physical activity reduces the risk of chronic illness including Type 2 diabetes, cardiovascular disease and certain types of cancer. Lifestyle interventions can increase physical activity but few successfully engage men. This study aims to investigate the 5 year cost-effectiveness of EuroFIT, a program to improve physical activity tailored specifically for male football (soccer) fans compared to a no intervention comparison group. METHODS: We developed a Markov cohort model in which the impact of improving physical activity on five chronic health conditions (colorectal cancer, Type 2 diabetes, coronary heart disease, stroke and depression) and mortality was modelled. We estimated costs from a societal perspective and expressed benefits as quality adjusted life years (QALYs). We obtained data from a 4-country (England, Netherlands, Portugal and Norway) pragmatic randomised controlled trial evaluating EuroFIT, epidemiological and cohort studies, and meta-analyses. We performed deterministic and probabilistic sensitivity analyses to assess the impact of uncertainty in the model’s parameter values on the cost-effectiveness results. We used Monte Carlo simulations to estimate uncertainty and presented this using cost-effectiveness acceptability curves (CEACs). We tested the robustness of the base case analysis using five scenario analyses. RESULTS: Average costs over 5 years per person receiving EuroFIT were €14,663 and per person receiving no intervention €14,598. Mean QALYs over 5 years were 4.05 per person for EuroFIT and 4.04 for no intervention. Thus, the average incremental cost per person receiving EuroFIT was €65 compared to no intervention, while the average QALY gain was 0.01. This resulted in an ICER of €5206 per QALY gained. CEACs show that the probability of EuroFIT being cost-effective compared to no intervention is 0.53, 0.56 and 0.58 at thresholds of €10,000, €22,000 and €34,000 per QALY gained, respectively. When using a time horizon of 10 years, the results suggest that EuroFIT is more effective and less expensive compared to (i.e. dominant over) no intervention with a probability of cost-effectiveness of 0.63 at a threshold of €22,000 per QALY gained. CONCLUSIONS: We conclude the EuroFIT intervention is not cost-effective compared to no intervention over a period of 5 years from a societal perspective, but is more effective and less expensive (i.e. dominant) after 10 years. We thus suggest that EuroFIT can potentially improve public health in a cost-effective manner in the long term. BioMed Central 2020-03-04 /pmc/articles/PMC7055048/ /pubmed/32131849 http://dx.doi.org/10.1186/s12966-020-00934-7 Text en © The Author(s) 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Kolovos, Spyros
Finch, Aureliano P.
van der Ploeg, Hidde P.
van Nassau, Femke
Broulikova, Hana M.
Baka, Agni
Treweek, Shaun
Gray, Cindy M.
Jelsma, Judith G. M.
Bunn, Christopher
Roberts, Glyn C.
Silva, Marlene N.
Gill, Jason M. R.
Røynesdal, Øystein
van Mechelen, Willem
Andersen, Eivind
Hunt, Kate
Wyke, Sally
Bosmans, Judith E.
Five-year cost-effectiveness analysis of the European Fans in Training (EuroFIT) physical activity intervention for men versus no intervention
title Five-year cost-effectiveness analysis of the European Fans in Training (EuroFIT) physical activity intervention for men versus no intervention
title_full Five-year cost-effectiveness analysis of the European Fans in Training (EuroFIT) physical activity intervention for men versus no intervention
title_fullStr Five-year cost-effectiveness analysis of the European Fans in Training (EuroFIT) physical activity intervention for men versus no intervention
title_full_unstemmed Five-year cost-effectiveness analysis of the European Fans in Training (EuroFIT) physical activity intervention for men versus no intervention
title_short Five-year cost-effectiveness analysis of the European Fans in Training (EuroFIT) physical activity intervention for men versus no intervention
title_sort five-year cost-effectiveness analysis of the european fans in training (eurofit) physical activity intervention for men versus no intervention
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055048/
https://www.ncbi.nlm.nih.gov/pubmed/32131849
http://dx.doi.org/10.1186/s12966-020-00934-7
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