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Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury
BACKGROUND: We have reported that polydatin (PD) alleviates mitochondrial dysfunction in rat models of sepsis-induced acute kidney injury (SI-AKI), but the mechanism is not well understood. Here, we investigated the role of Parkin-mediated mitophagy in the protective effects of PD in SI-AKI in mice....
Autores principales: | Gao, Youguang, Dai, Xingui, Li, Yunfeng, Li, Guicheng, Lin, Xianzhong, Ai, Chenmu, Cao, Yuanyuan, Li, Tao, Lin, Bo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055075/ https://www.ncbi.nlm.nih.gov/pubmed/32131850 http://dx.doi.org/10.1186/s12967-020-02283-2 |
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