Mesenchymal stem cell-derived exosomes protect beta cells against hypoxia-induced apoptosis via miR-21 by alleviating ER stress and inhibiting p38 MAPK phosphorylation

BACKGROUND: Hypoxia is a major cause of beta cell death and dysfunction after transplantation. The aim of this study was to investigate the effect of exosomes derived from mesenchymal stem cells (MSCs) on beta cells under hypoxic conditions and the potential underlying mechanisms. METHODS: Exosomes...

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Detalles Bibliográficos
Autores principales: Chen, Jin, Chen, Junqiu, Cheng, Yuanhang, Fu, Yunfeng, Zhao, Hongzhou, Tang, Minying, Zhao, Hu, Lin, Na, Shi, Xiaohua, Lei, Yan, Wang, Shuiliang, Huang, Lianghu, Wu, Weizhen, Tan, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055095/
https://www.ncbi.nlm.nih.gov/pubmed/32127037
http://dx.doi.org/10.1186/s13287-020-01610-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055095/
https://www.ncbi.nlm.nih.gov/pubmed/32127037
http://dx.doi.org/10.1186/s13287-020-01610-0

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