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Selective Targeting of Virus Replication by Proton Pump Inhibitors

Two proton pump inhibitors, tenatoprazole and esomeprazole, were previously shown to inhibit HIV-1 egress by blocking the interaction between Tsg101, a member of the ESCRT-I complex, and ubiquitin. Here, we deepen our understanding of prazole budding inhibition by studying a range of viruses in the...

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Detalles Bibliográficos
Autores principales: Watanabe, Susan M., Ehrlich, Lorna S., Strickland, Madeleine, Li, Xiaofan, Soloveva, Veronica, Goff, Arthur J., Stauft, Charles B., Bhaduri-McIntosh, Sumita, Tjandra, Nico, Carter, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055211/
https://www.ncbi.nlm.nih.gov/pubmed/32132561
http://dx.doi.org/10.1038/s41598-020-60544-y