Complete Profiling of Methyl-CpG-Binding Domains for Combinations of Cytosine Modifications at CpG Dinucleotides Reveals Differential Read-out in Normal and Rett-Associated States

5-Methylcytosine (mC) exists in CpG dinucleotides of mammalian DNA and plays key roles in chromatin regulation during development and disease. As a main regulatory pathway, fully methylated CpG are recognized by methyl-CpG-binding domain (MBD) proteins that act in concert with chromatin remodelers,...

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Detalles Bibliográficos
Autores principales: Buchmuller, Benjamin C., Kosel, Brinja, Summerer, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055227/
https://www.ncbi.nlm.nih.gov/pubmed/32132616
http://dx.doi.org/10.1038/s41598-020-61030-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055227/
https://www.ncbi.nlm.nih.gov/pubmed/32132616
http://dx.doi.org/10.1038/s41598-020-61030-1

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