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Morphometric development of the human fetal cerebellum during the early second trimester

The protracted nature of development makes the cerebellum vulnerable to a broad spectrum of pathologic conditions, especially during the early fetal period. This study aims to characterize normal cerebellar growth in human fetuses during the early second trimester. We manually segmented the fetal ce...

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Autores principales: Xu, Feifei, Ge, Xinting, Shi, Yonggang, Zhang, Zhonghe, Tang, Yuchun, Lin, Xiangtao, Teng, Gaojun, Zang, Fengchao, Gao, Nuonan, Liu, Haihong, Toga, Arthur W., Liu, Shuwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055298/
https://www.ncbi.nlm.nih.gov/pubmed/31751665
http://dx.doi.org/10.1016/j.neuroimage.2019.116372
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author Xu, Feifei
Ge, Xinting
Shi, Yonggang
Zhang, Zhonghe
Tang, Yuchun
Lin, Xiangtao
Teng, Gaojun
Zang, Fengchao
Gao, Nuonan
Liu, Haihong
Toga, Arthur W.
Liu, Shuwei
author_facet Xu, Feifei
Ge, Xinting
Shi, Yonggang
Zhang, Zhonghe
Tang, Yuchun
Lin, Xiangtao
Teng, Gaojun
Zang, Fengchao
Gao, Nuonan
Liu, Haihong
Toga, Arthur W.
Liu, Shuwei
author_sort Xu, Feifei
collection PubMed
description The protracted nature of development makes the cerebellum vulnerable to a broad spectrum of pathologic conditions, especially during the early fetal period. This study aims to characterize normal cerebellar growth in human fetuses during the early second trimester. We manually segmented the fetal cerebellum using 7.0-T high-resolution MR images obtained in 35 specimens with gestational ages ranging from 15 to 22 weeks. Volume measurements and shape analysis were performed to quantitatively evaluate global and regional cerebellar growth. The absolute volume of the fetal cerebellum showed a quadratic growth with increasing gestational age, while the pattern of relative volume changes revealed that the cerebellum grew at a greater pace than the cerebrum after 17 gestational weeks. Shape analysis was used to examine the distinctive development of subregions of the cerebellum. The extreme lateral portions of both cerebellar hemispheres showed the lowest rate of growth. The anterior lobe grew faster than most of the posterior lobe. These findings expand our understanding of the early growth pattern of the human cerebellum and could be further used to assess the developmental conditions of the fetal brain.
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spelling pubmed-70552982021-02-15 Morphometric development of the human fetal cerebellum during the early second trimester Xu, Feifei Ge, Xinting Shi, Yonggang Zhang, Zhonghe Tang, Yuchun Lin, Xiangtao Teng, Gaojun Zang, Fengchao Gao, Nuonan Liu, Haihong Toga, Arthur W. Liu, Shuwei Neuroimage Article The protracted nature of development makes the cerebellum vulnerable to a broad spectrum of pathologic conditions, especially during the early fetal period. This study aims to characterize normal cerebellar growth in human fetuses during the early second trimester. We manually segmented the fetal cerebellum using 7.0-T high-resolution MR images obtained in 35 specimens with gestational ages ranging from 15 to 22 weeks. Volume measurements and shape analysis were performed to quantitatively evaluate global and regional cerebellar growth. The absolute volume of the fetal cerebellum showed a quadratic growth with increasing gestational age, while the pattern of relative volume changes revealed that the cerebellum grew at a greater pace than the cerebrum after 17 gestational weeks. Shape analysis was used to examine the distinctive development of subregions of the cerebellum. The extreme lateral portions of both cerebellar hemispheres showed the lowest rate of growth. The anterior lobe grew faster than most of the posterior lobe. These findings expand our understanding of the early growth pattern of the human cerebellum and could be further used to assess the developmental conditions of the fetal brain. 2019-11-18 2020-02-15 /pmc/articles/PMC7055298/ /pubmed/31751665 http://dx.doi.org/10.1016/j.neuroimage.2019.116372 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Xu, Feifei
Ge, Xinting
Shi, Yonggang
Zhang, Zhonghe
Tang, Yuchun
Lin, Xiangtao
Teng, Gaojun
Zang, Fengchao
Gao, Nuonan
Liu, Haihong
Toga, Arthur W.
Liu, Shuwei
Morphometric development of the human fetal cerebellum during the early second trimester
title Morphometric development of the human fetal cerebellum during the early second trimester
title_full Morphometric development of the human fetal cerebellum during the early second trimester
title_fullStr Morphometric development of the human fetal cerebellum during the early second trimester
title_full_unstemmed Morphometric development of the human fetal cerebellum during the early second trimester
title_short Morphometric development of the human fetal cerebellum during the early second trimester
title_sort morphometric development of the human fetal cerebellum during the early second trimester
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055298/
https://www.ncbi.nlm.nih.gov/pubmed/31751665
http://dx.doi.org/10.1016/j.neuroimage.2019.116372
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