Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide

Pomalidomide, a derivative of thalidomide, is an effective treatment for multiple myeloma. The drug exerts its effects through CRBN, a component of the E3 ubiquitin ligase complex CRL4(CRBN). To search for novel factors involved in the anti-cancer activity of pomalidomide, we performed a genome-wide...

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Detalles Bibliográficos
Autores principales: Tateno, Shumpei, Iida, Midori, Fujii, Satoshi, Suwa, Tetsufumi, Katayama, Miki, Tokuyama, Haruka, Yamamoto, Junichi, Ito, Takumi, Sakamoto, Satoshi, Handa, Hiroshi, Yamaguchi, Yuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055313/
https://www.ncbi.nlm.nih.gov/pubmed/32132601
http://dx.doi.org/10.1038/s41598-020-61027-w

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