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Clinical and Neurocognitive Predictors of Functional Outcome in Depressed Patients with Partial Response to Treatment: One Year Follow-Up Study

BACKGROUND: Cognitive dysfunction represents a distinct biological and clinical dimension in major depression disorders (MDD) and cognitive performance strongly affects psychosocial functioning in patients diagnosed with MDD. OBJECTIVE: To assess which neurocognitive variables at baseline predict th...

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Autores principales: Castellano, Sabrina, Torrent, Carla, Petralia, Maria Cristina, Godos, Justyna, Cantarella, Rita Anna, Ventimiglia, Andrea, De Vivo, Simona, Platania, Silvia, Guarnera, Maria, Pirrone, Concetta, Drago, Filippo, Vieta, Eduard, Di Nuovo, Santo, Popovic, Dina, Caraci, Filippo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055477/
https://www.ncbi.nlm.nih.gov/pubmed/32184600
http://dx.doi.org/10.2147/NDT.S224754
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author Castellano, Sabrina
Torrent, Carla
Petralia, Maria Cristina
Godos, Justyna
Cantarella, Rita Anna
Ventimiglia, Andrea
De Vivo, Simona
Platania, Silvia
Guarnera, Maria
Pirrone, Concetta
Drago, Filippo
Vieta, Eduard
Di Nuovo, Santo
Popovic, Dina
Caraci, Filippo
author_facet Castellano, Sabrina
Torrent, Carla
Petralia, Maria Cristina
Godos, Justyna
Cantarella, Rita Anna
Ventimiglia, Andrea
De Vivo, Simona
Platania, Silvia
Guarnera, Maria
Pirrone, Concetta
Drago, Filippo
Vieta, Eduard
Di Nuovo, Santo
Popovic, Dina
Caraci, Filippo
author_sort Castellano, Sabrina
collection PubMed
description BACKGROUND: Cognitive dysfunction represents a distinct biological and clinical dimension in major depression disorders (MDD) and cognitive performance strongly affects psychosocial functioning in patients diagnosed with MDD. OBJECTIVE: To assess which neurocognitive variables at baseline predict the functional outcome of MDD patients in a 1-year follow-up study as assessed by Functioning Assessment Short Test (FAST) and whether the improvement observed on affective and cognitive symptoms in our 12 week-prospective observational study after treatment with selective serotonin reuptake inhibitors (SSRIs) and selective noradrenalin reuptake inhibitors (SNRIs) can affect the following long-term psychosocial functional outcome at 1 year in the same MDD patients. METHODS: We recruited a total of 31 patients (8 males; 23 females) with MDD who had previously completed a pharmacological treatment with SSRIs (n = 22) or SNRIs (n = 9) for 12 weeks, and then continued the same pharmacological treatment for 1 year. After an average 1-year follow-up, they were interviewed with the FAST to assess functional outcome. Multivariate analyses were applied to identify clinical and neurocognitive predictors of functional outcome. RESULTS: Total Montreal Cognitive Assessment (MoCA), Digit Span forward (Span F) and backward (Span B), and 15 Rey words immediate recall (Rey I) scores significantly correlated with FAST. However, after performing regression models only Rey immediate recall score was useful to predict long-term functional outcome (Pearson correlation coefficient R= −0.68, p < 0.001) in four specific subdomains of FAST. When considering changes in affective and cognitive symptoms at the end of the 12 weeks of pharmacological treatment with SSRI or SNRIs (T1-T0) by multiple regression analysis, we found that Span F-test predicted scores in the FAST leisure domain, whereas, changes in Span F, Frontal Assessment Battery (FAB) and Rey I predicted psychosocial functioning in the specific “cognitive” subdomains of FAST. CONCLUSION: Our data suggest that long-term psychosocial functioning can be influenced by neurocognitive performance at baseline, with verbal memory playing a key role in overall functioning. Furthermore, improvement in verbal memory can predict functional outcome at one year in MDD patients with a recent history of partial response to antidepressants.
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spelling pubmed-70554772020-03-17 Clinical and Neurocognitive Predictors of Functional Outcome in Depressed Patients with Partial Response to Treatment: One Year Follow-Up Study Castellano, Sabrina Torrent, Carla Petralia, Maria Cristina Godos, Justyna Cantarella, Rita Anna Ventimiglia, Andrea De Vivo, Simona Platania, Silvia Guarnera, Maria Pirrone, Concetta Drago, Filippo Vieta, Eduard Di Nuovo, Santo Popovic, Dina Caraci, Filippo Neuropsychiatr Dis Treat Original Research BACKGROUND: Cognitive dysfunction represents a distinct biological and clinical dimension in major depression disorders (MDD) and cognitive performance strongly affects psychosocial functioning in patients diagnosed with MDD. OBJECTIVE: To assess which neurocognitive variables at baseline predict the functional outcome of MDD patients in a 1-year follow-up study as assessed by Functioning Assessment Short Test (FAST) and whether the improvement observed on affective and cognitive symptoms in our 12 week-prospective observational study after treatment with selective serotonin reuptake inhibitors (SSRIs) and selective noradrenalin reuptake inhibitors (SNRIs) can affect the following long-term psychosocial functional outcome at 1 year in the same MDD patients. METHODS: We recruited a total of 31 patients (8 males; 23 females) with MDD who had previously completed a pharmacological treatment with SSRIs (n = 22) or SNRIs (n = 9) for 12 weeks, and then continued the same pharmacological treatment for 1 year. After an average 1-year follow-up, they were interviewed with the FAST to assess functional outcome. Multivariate analyses were applied to identify clinical and neurocognitive predictors of functional outcome. RESULTS: Total Montreal Cognitive Assessment (MoCA), Digit Span forward (Span F) and backward (Span B), and 15 Rey words immediate recall (Rey I) scores significantly correlated with FAST. However, after performing regression models only Rey immediate recall score was useful to predict long-term functional outcome (Pearson correlation coefficient R= −0.68, p < 0.001) in four specific subdomains of FAST. When considering changes in affective and cognitive symptoms at the end of the 12 weeks of pharmacological treatment with SSRI or SNRIs (T1-T0) by multiple regression analysis, we found that Span F-test predicted scores in the FAST leisure domain, whereas, changes in Span F, Frontal Assessment Battery (FAB) and Rey I predicted psychosocial functioning in the specific “cognitive” subdomains of FAST. CONCLUSION: Our data suggest that long-term psychosocial functioning can be influenced by neurocognitive performance at baseline, with verbal memory playing a key role in overall functioning. Furthermore, improvement in verbal memory can predict functional outcome at one year in MDD patients with a recent history of partial response to antidepressants. Dove 2020-02-28 /pmc/articles/PMC7055477/ /pubmed/32184600 http://dx.doi.org/10.2147/NDT.S224754 Text en © 2020 Castellano et al. http://creativecommons.org/licenses/by/4.0/ This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The full terms of the License are available at http://creativecommons.org/licenses/by/4.0/. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Research
Castellano, Sabrina
Torrent, Carla
Petralia, Maria Cristina
Godos, Justyna
Cantarella, Rita Anna
Ventimiglia, Andrea
De Vivo, Simona
Platania, Silvia
Guarnera, Maria
Pirrone, Concetta
Drago, Filippo
Vieta, Eduard
Di Nuovo, Santo
Popovic, Dina
Caraci, Filippo
Clinical and Neurocognitive Predictors of Functional Outcome in Depressed Patients with Partial Response to Treatment: One Year Follow-Up Study
title Clinical and Neurocognitive Predictors of Functional Outcome in Depressed Patients with Partial Response to Treatment: One Year Follow-Up Study
title_full Clinical and Neurocognitive Predictors of Functional Outcome in Depressed Patients with Partial Response to Treatment: One Year Follow-Up Study
title_fullStr Clinical and Neurocognitive Predictors of Functional Outcome in Depressed Patients with Partial Response to Treatment: One Year Follow-Up Study
title_full_unstemmed Clinical and Neurocognitive Predictors of Functional Outcome in Depressed Patients with Partial Response to Treatment: One Year Follow-Up Study
title_short Clinical and Neurocognitive Predictors of Functional Outcome in Depressed Patients with Partial Response to Treatment: One Year Follow-Up Study
title_sort clinical and neurocognitive predictors of functional outcome in depressed patients with partial response to treatment: one year follow-up study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055477/
https://www.ncbi.nlm.nih.gov/pubmed/32184600
http://dx.doi.org/10.2147/NDT.S224754
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