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Novel CB1 receptor antagonist BAR-1 modifies pancreatic islet function and clinical parameters in prediabetic and diabetic mice

BACKGROUDS: Cannabinoid receptor antagonists have been suggested as a novel treatment for obesity and diabetes. We have developed a synthetic cannabinoid receptor antagonist denominated BAR-1. As the function and integrity of a β-cell cellular structure are important keys for diabetes onset, we eval...

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Detalles Bibliográficos
Autores principales:	Nava-Molina, Lesly, Uchida-Fuentes, Toyokazu, Ramos-Tovar, Héctor, Fregoso-Padilla, Martha, Rodríguez-Monroy, Marco Aurelio, Vega, Ana V., Navarrete-Vázquez, Gabriel, Andrade-Jorge, Erik, Villalobos-Molina, Rafael, Ortiz-Ortega, Ricardo, Vilches-Flores, Alonso
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055595/ https://www.ncbi.nlm.nih.gov/pubmed/32132523 http://dx.doi.org/10.1038/s41387-020-0110-0

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