Cargando…

A Human REPIN1 Gene Variant: Genetic Risk Factor for the Development of Nonalcoholic Fatty Liver Disease

OBJECTIVES: We tested the hypothesis that a genetic deletion (Del) variant in the REPIN1 gene is associated with the severity of nonalcoholic fatty liver disease (NAFLD) in humans. METHODS: Sixty-three donors of liver biopsies from individuals with obesity and different degrees of NAFLD and fibrosis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abshagen, Kerstin, Berger, Claudia, Dietrich, Arne, Schütz, Tatjana, Wittekind, Christian, Stumvoll, Michael, Blüher, Matthias, Klöting, Nora
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056046/ https://www.ncbi.nlm.nih.gov/pubmed/31922994 http://dx.doi.org/10.14309/ctg.0000000000000114

Ejemplares similares

Liver-specific Repin1 deficiency impairs transient hepatic steatosis in liver regeneration
por: Abshagen, Kerstin, et al.
Publicado: (2018)

Repin1 deficiency in liver tissue alleviates NAFLD progression in mice
por: Abshagen, Kerstin, et al.
Publicado: (2018)

Curiosities of REPINs and RAYTs
por: Bertels, Frederic, et al.
Publicado: (2011)

Sex-Specific Effects of the Genetic Variant rs10487505 Upstream of leptin in the Development of Obesity
por: Molder, Janine, et al.
Publicado: (2023)

Tamoxifen treatment causes early hepatic insulin resistance
por: Klöting, Nora, et al.
Publicado: (2020)

REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis
por: Xia, Yu, et al.
Publicado: (2023)

Adipose Tissue Expression and Genetic Variants of the Bone Morphogenetic Protein Receptor 1A Gene (BMPR1A) Are Associated With Human Obesity
por: Böttcher, Yvonne, et al.
Publicado: (2009)

The polygenetically inherited metabolic syndrome of male WOKW rats is associated with enhanced autophagy in adipose tissue
por: Kosacka, Joanna, et al.
Publicado: (2013)

ADCY5 Gene Expression in Adipose Tissue Is Related to Obesity in Men and Mice
por: Knigge, Anja, et al.
Publicado: (2015)

Circulating cell adhesion molecules in metabolically healthy obesity
por: Mulhem, Arij, et al.
Publicado: (2020)

Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo
por: Zieger, Konstanze, et al.
Publicado: (2017)

COMP-Angiopoietin-1 Recovers Molecular Biomarkers of Neuropathy and Improves Vascularisation in Sciatic Nerve of ob/ob Mice
por: Kosacka, Joanna, et al.
Publicado: (2012)

Within-Genome Evolution of REPINs: a New Family of Miniature Mobile DNA in Bacteria
por: Bertels, Frederic, et al.
Publicado: (2011)

Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation
por: Weiner, Juliane, et al.
Publicado: (2017)

Ramipril Reduces Acylcarnitines and Distinctly Increases Angiotensin-Converting Enzyme 2 Expression in Lungs of Rats
por: Kosacka, Joanna, et al.
Publicado: (2022)

Associations between vitamin D, immunoglobulin E concentrations, and obesity
por: Avila Castillo, Angelica, et al.
Publicado: (2023)

Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue
por: Dommel, Sebastian, et al.
Publicado: (2021)

MicroRNA Expression in Human Omental and Subcutaneous Adipose Tissue
por: Klöting, Nora, et al.
Publicado: (2009)

Identification of Adipokine Clusters Related to Parameters of Fat Mass, Insulin Sensitivity and Inflammation
por: Flehmig, Gesine, et al.
Publicado: (2014)

Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance
por: Kannt, Aimo, et al.
Publicado: (2015)

Differential expression of immunoregulatory cytokines in adipose tissue and liver in response to high fat and high sugar diets in female mice
por: Weiner, Juliane, et al.
Publicado: (2023)

Effects of Weight Loss and Exercise on Apelin Serum Concentrations and Adipose Tissue Expression in Human Obesity
por: Krist, Joanna, et al.
Publicado: (2013)

Genetic predisposition in nonalcoholic fatty liver disease
por: Sookoian, Silvia, et al.
Publicado: (2017)

Circulating bacterial signature is linked to metabolic disease and shifts with metabolic alleviation after bariatric surgery
por: Chakaroun, Rima M., et al.
Publicado: (2021)

Screening for nonalcoholic fatty liver disease-when, who and how?
por: Dietrich, Christoph G, et al.
Publicado: (2021)

Leptin counteracts hypothermia in hypothyroidism through its pyrexic effects and by stabilizing serum thyroid hormone levels
por: Weiner, Juliane, et al.
Publicado: (2021)

Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma
por: Kikuchi, Luciana, et al.
Publicado: (2014)

Nonalcoholic Fatty Liver Disease
por: Filipović, Branka, et al.
Publicado: (2018)

Nonalcoholic fatty liver disease
por: Bebawi, Emmanuel, et al.
Publicado: (2023)

Vaspin inhibits kallikrein 7 by serpin mechanism
por: Heiker, John T., et al.
Publicado: (2013)

The Fabp4-Cre-Model is Insufficient to Study Hoxc9 Function in Adipose Tissue
por: Dommel, Sebastian, et al.
Publicado: (2020)

Effectiveness and Tolerability of a Two-Week Hypocaloric Protein-Rich Diet Prior to Obesity Surgery with Two Different Diet Interventions: a Prospective Randomized Trial
por: Lange, Undine Gabriele, et al.
Publicado: (2022)

Unique genetic variants of lean nonalcoholic fatty liver disease: a retrospective cohort study
por: Li, Jie, et al.
Publicado: (2023)

The transcontinental variability of nonalcoholic fatty liver disease
por: Oliveira, Claudia P., et al.
Publicado: (2020)

Hypoxia-inducible factor 3A gene expression and methylation in adipose tissue is related to adipose tissue dysfunction
por: Pfeiffer, Susanne, et al.
Publicado: (2016)

Is subcutaneous adipose tissue expansion in people living with lipedema healthier and reflected by circulating parameters?
por: Nankam, Pamela A. Nono, et al.
Publicado: (2022)

Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis
por: Dongiovanni, Paola, et al.
Publicado: (2015)

Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
por: Imajo, Kento, et al.
Publicado: (2013)

Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease
por: Pelusi, Serena, et al.
Publicado: (2019)

Genetic and Evolutionary Analyses of the Human Bone Morphogenetic Protein Receptor 2 (BMPR2) in the Pathophysiology of Obesity
por: Schleinitz, Dorit, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_kmkod6blj6ph04nlcri0dj7ke9