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Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

T cell expansion and differentiation are critically dependent on the transcription factor c-Myc (Myc). Herein we use quantitative mass-spectrometry to reveal how Myc controls antigen receptor driven cell growth and proteome restructuring in murine T cells. Analysis of copy numbers per cell of >70...

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Detalles Bibliográficos
Autores principales:	Marchingo, Julia M, Sinclair, Linda V, Howden, Andrew JM, Cantrell, Doreen A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056270/ https://www.ncbi.nlm.nih.gov/pubmed/32022686 http://dx.doi.org/10.7554/eLife.53725

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