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The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation

Networks of neurons control feeding and activity patterns by integrating internal metabolic signals of energy balance with external environmental cues such as time-of-day. Proper circadian alignment of feeding behavior is necessary to prevent metabolic disease, and thus it is imperative that molecul...

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Autores principales: Podyma, Brandon, Johnson, Dove-Anna, Sipe, Laura, Remcho, Thomas Parks, Battin, Katherine, Liu, Yuxi, Yoon, Sung Ok, Deppmann, Christopher D, Güler, Ali Deniz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056271/
https://www.ncbi.nlm.nih.gov/pubmed/31995032
http://dx.doi.org/10.7554/eLife.52623
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author Podyma, Brandon
Johnson, Dove-Anna
Sipe, Laura
Remcho, Thomas Parks
Battin, Katherine
Liu, Yuxi
Yoon, Sung Ok
Deppmann, Christopher D
Güler, Ali Deniz
author_facet Podyma, Brandon
Johnson, Dove-Anna
Sipe, Laura
Remcho, Thomas Parks
Battin, Katherine
Liu, Yuxi
Yoon, Sung Ok
Deppmann, Christopher D
Güler, Ali Deniz
author_sort Podyma, Brandon
collection PubMed
description Networks of neurons control feeding and activity patterns by integrating internal metabolic signals of energy balance with external environmental cues such as time-of-day. Proper circadian alignment of feeding behavior is necessary to prevent metabolic disease, and thus it is imperative that molecular players that maintain neuronal coordination of energy homeostasis are identified. Here, we demonstrate that mice lacking the p75 neurotrophin receptor, p75NTR, decrease their feeding and food anticipatory behavior (FAA) in response to daytime, but not nighttime, restricted feeding. These effects lead to increased weight loss, but do not require p75NTR during development. Instead, p75NTR is required for fasting-induced activation of neurons within the arcuate hypothalamus. Indeed, p75NTR specifically in AgRP neurons is required for FAA in response to daytime restricted feeding. These findings establish p75NTR as a novel regulator gating behavioral response to food scarcity and time-of-day dependence of circadian food anticipation.
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spelling pubmed-70562712020-03-05 The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation Podyma, Brandon Johnson, Dove-Anna Sipe, Laura Remcho, Thomas Parks Battin, Katherine Liu, Yuxi Yoon, Sung Ok Deppmann, Christopher D Güler, Ali Deniz eLife Neuroscience Networks of neurons control feeding and activity patterns by integrating internal metabolic signals of energy balance with external environmental cues such as time-of-day. Proper circadian alignment of feeding behavior is necessary to prevent metabolic disease, and thus it is imperative that molecular players that maintain neuronal coordination of energy homeostasis are identified. Here, we demonstrate that mice lacking the p75 neurotrophin receptor, p75NTR, decrease their feeding and food anticipatory behavior (FAA) in response to daytime, but not nighttime, restricted feeding. These effects lead to increased weight loss, but do not require p75NTR during development. Instead, p75NTR is required for fasting-induced activation of neurons within the arcuate hypothalamus. Indeed, p75NTR specifically in AgRP neurons is required for FAA in response to daytime restricted feeding. These findings establish p75NTR as a novel regulator gating behavioral response to food scarcity and time-of-day dependence of circadian food anticipation. eLife Sciences Publications, Ltd 2020-01-29 /pmc/articles/PMC7056271/ /pubmed/31995032 http://dx.doi.org/10.7554/eLife.52623 Text en © 2020, Podyma et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Podyma, Brandon
Johnson, Dove-Anna
Sipe, Laura
Remcho, Thomas Parks
Battin, Katherine
Liu, Yuxi
Yoon, Sung Ok
Deppmann, Christopher D
Güler, Ali Deniz
The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation
title The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation
title_full The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation
title_fullStr The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation
title_full_unstemmed The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation
title_short The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation
title_sort p75 neurotrophin receptor in agrp neurons is necessary for homeostatic feeding and food anticipation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056271/
https://www.ncbi.nlm.nih.gov/pubmed/31995032
http://dx.doi.org/10.7554/eLife.52623
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