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The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation
Networks of neurons control feeding and activity patterns by integrating internal metabolic signals of energy balance with external environmental cues such as time-of-day. Proper circadian alignment of feeding behavior is necessary to prevent metabolic disease, and thus it is imperative that molecul...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056271/ https://www.ncbi.nlm.nih.gov/pubmed/31995032 http://dx.doi.org/10.7554/eLife.52623 |
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author | Podyma, Brandon Johnson, Dove-Anna Sipe, Laura Remcho, Thomas Parks Battin, Katherine Liu, Yuxi Yoon, Sung Ok Deppmann, Christopher D Güler, Ali Deniz |
author_facet | Podyma, Brandon Johnson, Dove-Anna Sipe, Laura Remcho, Thomas Parks Battin, Katherine Liu, Yuxi Yoon, Sung Ok Deppmann, Christopher D Güler, Ali Deniz |
author_sort | Podyma, Brandon |
collection | PubMed |
description | Networks of neurons control feeding and activity patterns by integrating internal metabolic signals of energy balance with external environmental cues such as time-of-day. Proper circadian alignment of feeding behavior is necessary to prevent metabolic disease, and thus it is imperative that molecular players that maintain neuronal coordination of energy homeostasis are identified. Here, we demonstrate that mice lacking the p75 neurotrophin receptor, p75NTR, decrease their feeding and food anticipatory behavior (FAA) in response to daytime, but not nighttime, restricted feeding. These effects lead to increased weight loss, but do not require p75NTR during development. Instead, p75NTR is required for fasting-induced activation of neurons within the arcuate hypothalamus. Indeed, p75NTR specifically in AgRP neurons is required for FAA in response to daytime restricted feeding. These findings establish p75NTR as a novel regulator gating behavioral response to food scarcity and time-of-day dependence of circadian food anticipation. |
format | Online Article Text |
id | pubmed-7056271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-70562712020-03-05 The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation Podyma, Brandon Johnson, Dove-Anna Sipe, Laura Remcho, Thomas Parks Battin, Katherine Liu, Yuxi Yoon, Sung Ok Deppmann, Christopher D Güler, Ali Deniz eLife Neuroscience Networks of neurons control feeding and activity patterns by integrating internal metabolic signals of energy balance with external environmental cues such as time-of-day. Proper circadian alignment of feeding behavior is necessary to prevent metabolic disease, and thus it is imperative that molecular players that maintain neuronal coordination of energy homeostasis are identified. Here, we demonstrate that mice lacking the p75 neurotrophin receptor, p75NTR, decrease their feeding and food anticipatory behavior (FAA) in response to daytime, but not nighttime, restricted feeding. These effects lead to increased weight loss, but do not require p75NTR during development. Instead, p75NTR is required for fasting-induced activation of neurons within the arcuate hypothalamus. Indeed, p75NTR specifically in AgRP neurons is required for FAA in response to daytime restricted feeding. These findings establish p75NTR as a novel regulator gating behavioral response to food scarcity and time-of-day dependence of circadian food anticipation. eLife Sciences Publications, Ltd 2020-01-29 /pmc/articles/PMC7056271/ /pubmed/31995032 http://dx.doi.org/10.7554/eLife.52623 Text en © 2020, Podyma et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Podyma, Brandon Johnson, Dove-Anna Sipe, Laura Remcho, Thomas Parks Battin, Katherine Liu, Yuxi Yoon, Sung Ok Deppmann, Christopher D Güler, Ali Deniz The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation |
title | The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation |
title_full | The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation |
title_fullStr | The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation |
title_full_unstemmed | The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation |
title_short | The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation |
title_sort | p75 neurotrophin receptor in agrp neurons is necessary for homeostatic feeding and food anticipation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056271/ https://www.ncbi.nlm.nih.gov/pubmed/31995032 http://dx.doi.org/10.7554/eLife.52623 |
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