Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs

The rapid evolution of resistance alleles poses a major obstacle for genetic manipulation of populations with CRISPR homing gene drives. One proposed solution is using multiple guide RNAs (gRNAs), allowing a drive to function even if some resistant target sites are present. Here, we develop a model...

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Detalles Bibliográficos
Autores principales: Champer, Samuel E., Oh, Suh Yeon, Liu, Chen, Wen, Zhaoxin, Clark, Andrew G., Messer, Philipp W., Champer, Jackson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056305/
https://www.ncbi.nlm.nih.gov/pubmed/32181354
http://dx.doi.org/10.1126/sciadv.aaz0525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056305/
https://www.ncbi.nlm.nih.gov/pubmed/32181354
http://dx.doi.org/10.1126/sciadv.aaz0525

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