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T-cell Lymphoma Presenting Neutrophilic Inflammation in the Cerebrospinal Fluid
A 66-year-old woman presented with upper abdominal pain and weakness in the limbs. She had bilateral uveitis and gastric ulcers. A neurological examination revealed tetraparesis and sensory disturbance in the right arm. A cerebrospinal fluid (CSF) examination showed polymorphonuclear pleocytosis wit...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056371/ https://www.ncbi.nlm.nih.gov/pubmed/31588077 http://dx.doi.org/10.2169/internalmedicine.3093-19 |
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author | Nakamura, Takaaki Takai, Yoshiki Kaneko, Kimihiko Kuroda, Hiroshi Misu, Tatsuro Asanuma, Kiyotaka Saito, Ryoko Aoki, Masashi |
author_facet | Nakamura, Takaaki Takai, Yoshiki Kaneko, Kimihiko Kuroda, Hiroshi Misu, Tatsuro Asanuma, Kiyotaka Saito, Ryoko Aoki, Masashi |
author_sort | Nakamura, Takaaki |
collection | PubMed |
description | A 66-year-old woman presented with upper abdominal pain and weakness in the limbs. She had bilateral uveitis and gastric ulcers. A neurological examination revealed tetraparesis and sensory disturbance in the right arm. A cerebrospinal fluid (CSF) examination showed polymorphonuclear pleocytosis with elevated pro-inflammatory cytokine levels. Magnetic resonance imaging showed brain lesions and a long spinal cord lesion. She was initially diagnosed with neuro-Behçet's disease and was treated with corticosteroids, resulting in no improvement. A gastric mucosa biopsy indicated T-cell lymphoma colocalizing with neutrophils. The cytokine-mediated neutrophilic inflammation probably caused characteristic CSF and histopathological features. It is noteworthy that T-cell lymphoma may present with CSF neutrophilic inflammation. |
format | Online Article Text |
id | pubmed-7056371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-70563712020-03-05 T-cell Lymphoma Presenting Neutrophilic Inflammation in the Cerebrospinal Fluid Nakamura, Takaaki Takai, Yoshiki Kaneko, Kimihiko Kuroda, Hiroshi Misu, Tatsuro Asanuma, Kiyotaka Saito, Ryoko Aoki, Masashi Intern Med Case Report A 66-year-old woman presented with upper abdominal pain and weakness in the limbs. She had bilateral uveitis and gastric ulcers. A neurological examination revealed tetraparesis and sensory disturbance in the right arm. A cerebrospinal fluid (CSF) examination showed polymorphonuclear pleocytosis with elevated pro-inflammatory cytokine levels. Magnetic resonance imaging showed brain lesions and a long spinal cord lesion. She was initially diagnosed with neuro-Behçet's disease and was treated with corticosteroids, resulting in no improvement. A gastric mucosa biopsy indicated T-cell lymphoma colocalizing with neutrophils. The cytokine-mediated neutrophilic inflammation probably caused characteristic CSF and histopathological features. It is noteworthy that T-cell lymphoma may present with CSF neutrophilic inflammation. The Japanese Society of Internal Medicine 2019-10-07 2020-02-15 /pmc/articles/PMC7056371/ /pubmed/31588077 http://dx.doi.org/10.2169/internalmedicine.3093-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Nakamura, Takaaki Takai, Yoshiki Kaneko, Kimihiko Kuroda, Hiroshi Misu, Tatsuro Asanuma, Kiyotaka Saito, Ryoko Aoki, Masashi T-cell Lymphoma Presenting Neutrophilic Inflammation in the Cerebrospinal Fluid |
title | T-cell Lymphoma Presenting Neutrophilic Inflammation in the Cerebrospinal Fluid |
title_full | T-cell Lymphoma Presenting Neutrophilic Inflammation in the Cerebrospinal Fluid |
title_fullStr | T-cell Lymphoma Presenting Neutrophilic Inflammation in the Cerebrospinal Fluid |
title_full_unstemmed | T-cell Lymphoma Presenting Neutrophilic Inflammation in the Cerebrospinal Fluid |
title_short | T-cell Lymphoma Presenting Neutrophilic Inflammation in the Cerebrospinal Fluid |
title_sort | t-cell lymphoma presenting neutrophilic inflammation in the cerebrospinal fluid |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056371/ https://www.ncbi.nlm.nih.gov/pubmed/31588077 http://dx.doi.org/10.2169/internalmedicine.3093-19 |
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