Neuropsychiatric Immune-related Adverse Events Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma and Systemic Lupus Erythematosus

The patient was a 73-year-old woman with lung adenocarcinoma and systemic lupus erythematosus (SLE) who was treated with pembrolizumab. After six cycles of pembrolizumab, she developed symptoms suggestive of neuropsychiatric SLE, such as resting tremor, confusional state, depression, mood disorder,...

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Autores principales: Jono, Misato, Kinehara, Yuhei, Utsu, Yoshihiko, Tamura, Yoshiro, Koseto, Masahiro, Murakami, Teruaki, Uota, Akifumi, Ninomiya, Ryusuke, Komo, Satoshi, Sumitani, Satoru, Sato, Bunzo, Kasayama, Soji, Tachibana, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056375/
https://www.ncbi.nlm.nih.gov/pubmed/31666468
http://dx.doi.org/10.2169/internalmedicine.3782-19
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author Jono, Misato
Kinehara, Yuhei
Utsu, Yoshihiko
Tamura, Yoshiro
Koseto, Masahiro
Murakami, Teruaki
Uota, Akifumi
Ninomiya, Ryusuke
Komo, Satoshi
Sumitani, Satoru
Sato, Bunzo
Kasayama, Soji
Tachibana, Isao
author_facet Jono, Misato
Kinehara, Yuhei
Utsu, Yoshihiko
Tamura, Yoshiro
Koseto, Masahiro
Murakami, Teruaki
Uota, Akifumi
Ninomiya, Ryusuke
Komo, Satoshi
Sumitani, Satoru
Sato, Bunzo
Kasayama, Soji
Tachibana, Isao
author_sort Jono, Misato
collection PubMed
description The patient was a 73-year-old woman with lung adenocarcinoma and systemic lupus erythematosus (SLE) who was treated with pembrolizumab. After six cycles of pembrolizumab, she developed symptoms suggestive of neuropsychiatric SLE, such as resting tremor, confusional state, depression, mood disorder, and anxiety disorder. In addition, her cerebrospinal fluid level of interleukin-6 was elevated. Her symptoms resolved one month after the discontinuation of pembrolizumab. This is the first report of neuropsychiatric symptoms in a patient with lung cancer and SLE on immune checkpoint blockade therapy.
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spelling pubmed-70563752020-03-05 Neuropsychiatric Immune-related Adverse Events Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma and Systemic Lupus Erythematosus Jono, Misato Kinehara, Yuhei Utsu, Yoshihiko Tamura, Yoshiro Koseto, Masahiro Murakami, Teruaki Uota, Akifumi Ninomiya, Ryusuke Komo, Satoshi Sumitani, Satoru Sato, Bunzo Kasayama, Soji Tachibana, Isao Intern Med Case Report The patient was a 73-year-old woman with lung adenocarcinoma and systemic lupus erythematosus (SLE) who was treated with pembrolizumab. After six cycles of pembrolizumab, she developed symptoms suggestive of neuropsychiatric SLE, such as resting tremor, confusional state, depression, mood disorder, and anxiety disorder. In addition, her cerebrospinal fluid level of interleukin-6 was elevated. Her symptoms resolved one month after the discontinuation of pembrolizumab. This is the first report of neuropsychiatric symptoms in a patient with lung cancer and SLE on immune checkpoint blockade therapy. The Japanese Society of Internal Medicine 2019-10-31 2020-02-15 /pmc/articles/PMC7056375/ /pubmed/31666468 http://dx.doi.org/10.2169/internalmedicine.3782-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Jono, Misato
Kinehara, Yuhei
Utsu, Yoshihiko
Tamura, Yoshiro
Koseto, Masahiro
Murakami, Teruaki
Uota, Akifumi
Ninomiya, Ryusuke
Komo, Satoshi
Sumitani, Satoru
Sato, Bunzo
Kasayama, Soji
Tachibana, Isao
Neuropsychiatric Immune-related Adverse Events Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma and Systemic Lupus Erythematosus
title Neuropsychiatric Immune-related Adverse Events Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma and Systemic Lupus Erythematosus
title_full Neuropsychiatric Immune-related Adverse Events Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma and Systemic Lupus Erythematosus
title_fullStr Neuropsychiatric Immune-related Adverse Events Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma and Systemic Lupus Erythematosus
title_full_unstemmed Neuropsychiatric Immune-related Adverse Events Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma and Systemic Lupus Erythematosus
title_short Neuropsychiatric Immune-related Adverse Events Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma and Systemic Lupus Erythematosus
title_sort neuropsychiatric immune-related adverse events induced by pembrolizumab in a patient with lung adenocarcinoma and systemic lupus erythematosus
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056375/
https://www.ncbi.nlm.nih.gov/pubmed/31666468
http://dx.doi.org/10.2169/internalmedicine.3782-19
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