Cargando…

ALK5 deficiency inhibits macrophage inflammation and lipid loading by targeting KLF4

The transforming growth factor type-β (TGF-β) has been demonstrated to play an important role in the development of atherosclerosis through binding to the serine/threonine kinase transmembrane type I and type II receptors. However, as a key type I receptor for TGF-β, the exact role and the underlyin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Wenyan, Wang, Junhua, Li, Zhaofeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Cardiovascular System & Vascular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056445/ https://www.ncbi.nlm.nih.gov/pubmed/32065217 http://dx.doi.org/10.1042/BSR20194188

Ejemplares similares

Pioglitazone protects blood vessels through inhibition of the apelin signaling pathway by promoting KLF4 expression in rat models of T2DM
por: Wang, Ying, et al.
Publicado: (2019)

Catestatin prevents endothelial inflammation and promotes thrombus resolution in acute pulmonary embolism in mice
por: Chen, Hua, et al.
Publicado: (2019)

Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy
por: Walton, Sarah L., et al.
Publicado: (2020)

Inflammation: a putative link between phosphate metabolism and cardiovascular disease
por: Voelkl, Jakob, et al.
Publicado: (2021)

Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats
por: Mary, Sheon, et al.
Publicado: (2021)

LncRNA NRON alleviates atrial fibrosis through suppression of M1 macrophages activated by atrial myocytes
por: Sun, Fei, et al.
Publicado: (2019)

Inhibition of microRNA-146a attenuated heart failure in myocardial infarction rats
por: He, Junjie, et al.
Publicado: (2019)

Endostatin attenuates heart failure via inhibiting reactive oxygen species in myocardial infarction rats
por: Xu, Xuguang, et al.
Publicado: (2021)

Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice
por: Wang, Shu-Huei, et al.
Publicado: (2023)

PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses
por: Marshall, Jacqueline J.T., et al.
Publicado: (2022)

Reduction of TMAO level enhances the stability of carotid atherosclerotic plaque through promoting macrophage M2 polarization and efferocytosis
por: Shi, Weihao, et al.
Publicado: (2021)

The correlation between trimethylamine N-oxide, lipoprotein ratios, and conventional lipid parameters in patients with unstable angina pectoris
por: Dong, Zeng-Xiang, et al.
Publicado: (2020)

Statin-induced microRNAome alterations modulating inflammation pathways of peripheral blood mononuclear cells in patients with hypercholesterolemia
por: Lin, Hung-Ju, et al.
Publicado: (2020)

Vitamin D deficiency promotes large rupture-prone abdominal aortic aneurysms and cholecalciferol supplementation limits progression of aneurysms in a mouse model
por: Nsengiyumva, Vianne, et al.
Publicado: (2020)

MiR-377-3p inhibits atherosclerosis-associated vascular smooth muscle cell proliferation and migration via targeting neuropilin2
por: Wang, Haijun, et al.
Publicado: (2020)

The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension
por: Meijles, Daniel N., et al.
Publicado: (2021)

Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage
por: Mirabito Colafella, Katrina M., et al.
Publicado: (2022)

Inhibition of smooth muscle cell death by Angiotensin 1-7 protects against abdominal aortic aneurysm
por: Jadli, Anshul S., et al.
Publicado: (2023)

MiR-489 aggravates H(2)O(2)-induced apoptosis of cardiomyocytes via inhibiting IGF1
por: Tang, Shan, et al.
Publicado: (2020)

Beneficial effects of brief early life angiotensin-converting enzyme inhibition wane with time in sheep with solitary functioning kidney
por: McArdle, Zoe, et al.
Publicado: (2023)

Combined detection of miR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 for screening of early heart failure diseases
por: Ding, Han, et al.
Publicado: (2020)

Apelin-13 alleviated cardiac fibrosis via inhibiting the PI3K/Akt pathway to attenuate oxidative stress in rats with myocardial infarction-induced heart failure
por: Zhong, Shan, et al.
Publicado: (2020)

Sappanone A alleviates hypoxia/reoxygenation-induced cardiomyocytes injury through inhibition of mitochondrial apoptosis and activation of PI3K–Akt–Gsk-3β pathway
por: Shi, Xiaojing, et al.
Publicado: (2020)

MicroRNA-132 attenuated cardiac fibrosis in myocardial infarction-induced heart failure rats
por: Wang, Guoyu, et al.
Publicado: (2020)

Src tyrosine kinase promotes cardiac remodeling induced by chronic sympathetic activation
por: Li, Wenqi, et al.
Publicado: (2023)

Identification of biomarkers and immune infiltration in acute myocardial infarction and heart failure by integrated analysis
por: Liu, Wei, et al.
Publicado: (2023)

IL-1β promotes hypoxic vascular endothelial cell proliferation through the miR-24-3p/NKAP/NF-κB axis
por: Huang, Jiangnan, et al.
Publicado: (2022)

Research progress of ghrelin on cardiovascular disease
por: Yuan, Ming-Jie, et al.
Publicado: (2021)

Paternal long-term PM(2.5) exposure causes hypertension via increased renal AT(1)R expression and function in male offspring
por: Hu, Cuimei, et al.
Publicado: (2021)

Association between polymorphisms in interleukin-18 promoter and risk of coronary artery disease: a meta-analysis
por: Lian, Zheng, et al.
Publicado: (2019)

Gut microbiota in coronary artery disease: a friend or foe?
por: Zhang, Bo, et al.
Publicado: (2020)

Effect of miR-195-5p on cardiomyocyte apoptosis in rats with heart failure by regulating TGF-β1/Smad3 signaling pathway
por: Xie, Chun, et al.
Publicado: (2020)

Colchicine protects against the development of experimental abdominal aortic aneurysm
por: Zhao, Yi, et al.
Publicado: (2023)

Experimental evidence and network pharmacology-based analysis reveal the molecular mechanism of Tongxinluo capsule administered in coronary heart diseases
por: Li, Guode, et al.
Publicado: (2020)

Effects of nebivolol versus other antihypertensive drugs on the endothelial dysfunction in patients with essential hypertension
por: Li, Bingwei, et al.
Publicado: (2020)

The different associations between platelet distribution width and hypertension subtypes in males and females
por: Li, Tingwei, et al.
Publicado: (2020)

Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca(2+) mishandling and atrial fibrosis in active immunization rabbit models
por: Sun, Huaxin, et al.
Publicado: (2023)

Association between plasma betaine levels and dysglycemia in patients with coronary artery disease
por: Guo, Fei, et al.
Publicado: (2020)

Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension
por: Jiang, Hongxia, et al.
Publicado: (2021)

ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE(−/−) mice
por: Yu, Huahui, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_de72omt3rv011sqbvsf6b150eo