CRISPR-Cas13a Cleavage of Dengue Virus NS3 Gene Efficiently Inhibits Viral Replication

The CRISPR-Cas9 system has been applied to DNA editing with precision in eukaryotic and prokaryotic systems, but it is unable to edit RNA directly. A recently developed CRISPR-Cas13a system has been shown to be capable of effectively knocking down RNA expression in mammalian and plant cells. In this...

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Detalles Bibliográficos
Autores principales: Li, Hao, Wang, Shan, Dong, Xue, Li, Qiao, Li, Min, Li, Junfeng, Guo, Yan, Jin, Xia, Zhou, Yusen, Song, Hongbin, Kou, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056623/
https://www.ncbi.nlm.nih.gov/pubmed/32160714
http://dx.doi.org/10.1016/j.omtn.2020.01.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056623/
https://www.ncbi.nlm.nih.gov/pubmed/32160714
http://dx.doi.org/10.1016/j.omtn.2020.01.028

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