Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity

There has been extensive discussion of the “Replication Crisis” in many fields, including genome-wide association studies (GWAS). We explored replication in a mouse model using an advanced intercross line (AIL), which is a multigenerational intercross between two inbred strains. We re-genotyped a pr...

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Detalles Bibliográficos
Autores principales: Zhou, Xinzhu, St. Pierre, Celine L., Gonzales, Natalia M., Zou, Jennifer, Cheng, Riyan, Chitre, Apurva S., Sokoloff, Greta, Palmer, Abraham A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2020
Materias:
Multiparental Populations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056977/
https://www.ncbi.nlm.nih.gov/pubmed/31974095
http://dx.doi.org/10.1534/g3.119.400763

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